Enantiopure 3,7-diazabicyclo[3.3.1]nonane derivatives 4 and 5, potential precursors of quinolizidine alkaloids, were synthesised in high yields, starting from the biocatalytic asymmetrization of sigma-symmetric 3,5-disubstituted piperidines. Their application to the total synthesis of the new pharmacologically active compounds 3 are also described. (C) 1999 Elsevier Science Ltd. All rights reserved.
An efficient chemoenzymatic access to chiral 3,7-diazabicyclo[3.3.1]nonane derivatives / B. Danieli, G. Lesma, D. Passarella, A. Silvani, N. Viviani. - In: TETRAHEDRON. - ISSN 0040-4020. - 55:40(1999), pp. 11871-11878. [10.1016/S0040-4020(99)00674-2]
An efficient chemoenzymatic access to chiral 3,7-diazabicyclo[3.3.1]nonane derivatives
B. DanieliPrimo
;G. LesmaSecondo
;D. Passarella;A. SilvaniPenultimo
;
1999
Abstract
Enantiopure 3,7-diazabicyclo[3.3.1]nonane derivatives 4 and 5, potential precursors of quinolizidine alkaloids, were synthesised in high yields, starting from the biocatalytic asymmetrization of sigma-symmetric 3,5-disubstituted piperidines. Their application to the total synthesis of the new pharmacologically active compounds 3 are also described. (C) 1999 Elsevier Science Ltd. All rights reserved.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
