A mixture of dimethyl 1-benzyl-cis- and trans-piperidine-3,5-dicarboxylate is prepared in high yields from readily available starting materials, by a reliable procedure. The straightforward conversion of the mixture into the diastereomerically pure cis-isomer, a useful sigma-symmetry intermediate for alkaloid synthesis, is also described.
An expeditious synthesis of dimethyl 1-benzyl-cis-piperidine-3,5-dicarboxylate / B. Danieli, G. Lesma, D. Passarella, A. Silvani. - In: SYNTHETIC COMMUNICATIONS. - ISSN 0039-7911. - 27:1(1997), pp. 69-77.
An expeditious synthesis of dimethyl 1-benzyl-cis-piperidine-3,5-dicarboxylate
B. DanieliPrimo
;G. LesmaSecondo
;D. PassarellaPenultimo
;A. SilvaniUltimo
1997
Abstract
A mixture of dimethyl 1-benzyl-cis- and trans-piperidine-3,5-dicarboxylate is prepared in high yields from readily available starting materials, by a reliable procedure. The straightforward conversion of the mixture into the diastereomerically pure cis-isomer, a useful sigma-symmetry intermediate for alkaloid synthesis, is also described.File in questo prodotto:
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