Thienopyridines are commonly used antiplatelet drugs that may be associated with the development of secondary, drug-induced thrombotic thrombocytopenic purpura (TTP), a rare but potentially life threatening condition. We report the case of a 70 year-old man with a history of recurrent idiopathic TTP episodes who was treated with clopidogrel and then ticlopidine for thromboprophylaxis after percutaneous coronary intervention. Treatment was successful with no signs of TTP recurrence. Platelet counts and ADAMTS13 activity levels remained normal for months after the initiation of anti-platelet therapy, with no reappearance of anti-ADAMTS13 autoantibodies. This report demonstrates that thienopyridines do not necessarily induce TTP in patients with a history of TTP who are in disease remission.

Case report : use of thienopyridines in a patient with acquired idiopathic thrombotic thrombocytopenic purpura / L.A. Lotta, I. Mancini, G. Tuana, K.M. Musallam, F. Peyvandi. - In: JOURNAL OF THROMBOSIS AND THROMBOLYSIS. - ISSN 0929-5305. - 34:3(2012 Oct), pp. 416-418. [10.1007/s11239-012-0717-7]

Case report : use of thienopyridines in a patient with acquired idiopathic thrombotic thrombocytopenic purpura

L.A. Lotta
Primo
;
I. Mancini
Secondo
;
F. Peyvandi
Ultimo
2012-10

Abstract

Thienopyridines are commonly used antiplatelet drugs that may be associated with the development of secondary, drug-induced thrombotic thrombocytopenic purpura (TTP), a rare but potentially life threatening condition. We report the case of a 70 year-old man with a history of recurrent idiopathic TTP episodes who was treated with clopidogrel and then ticlopidine for thromboprophylaxis after percutaneous coronary intervention. Treatment was successful with no signs of TTP recurrence. Platelet counts and ADAMTS13 activity levels remained normal for months after the initiation of anti-platelet therapy, with no reappearance of anti-ADAMTS13 autoantibodies. This report demonstrates that thienopyridines do not necessarily induce TTP in patients with a history of TTP who are in disease remission.
ADAMTS13; Clopidogrel; Drug-induced thrombotic thrombocytopenic purpura; Thrombotic thrombocytopenic purpura; Ticlopidine; VWF
Settore MED/09 - Medicina Interna
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/176770
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