N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a Scaffold for the Synthesis of Inhibitors of Bcr-Abl

N-[2-methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine derivatives were synthesized and evaluated in vitro for their potential use as inhibitors of Bcr-Abl. The design is based on the bioisosterism between the triazole ring and the amide group. The synthesis presents a copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) as a key step with the solo obtainment of the anti-(1,4)-triazole derivatives. One of the obtained compounds showed a noteworthy general activity comparable to Imatinib and in particular it resulted more effective in reducing the fundamental function of cdc25A phosphatases in K-562 cell line.