Background: Cigarette smoking (CS) is a determinant of carotid atherosclerosis. Among mechanisms potentially responsible of this effect, e.g activation of extensive peroxidation processes, changes of fatty acid (FA) levels in smokers, especially the reduction of polyunsaturated FA (PUFA) in plasma and tissues, may be involved. Objective: To evaluate whether CS interacts with circulating FA in affecting the individual values of carotid artery intima media thickness (C-IMT). Methods: Plasma FA composition of 32 Smokers and 32 Never-smokers, matched for age, sex and status of hypercholesterolemia was determined by GC analysis after FA transmethylation. C-IMT was measured by Bmode ultrasound. To reach the study objective, correlations between C-IMT and each FA were investigated in both smokers and never-smokers and interactions assessed. Results: As expected, saturated (14:0, 16:0) and monounsaturated (16:1, 18:1, 24:1) FA were higher and PUFA (20:4 n-6 and 22:5, 22:6 n-3) were lower in Smokers than in Never-smokers. The effect of CS on FA was dosedependent for both 20:1 and 18:3 n-3, where a negative correlation with pack-years, an index of global smoking exposure, was found (r=-0.402, p=0.015 and r=-0.346,p=0.039, respectively). Interactions were evaluated after adjustment for fibrate therapy (the unique variable for which the two groups differ) as well as for matching (an adjustment done to take into account that groups were matched). CS significantly interacts with 20:3 n-6 (Binteraction=-0.16), 20:5 n-3 (Binteraction=0.25), 22:5 n-3 (Binteraction=0.43), 22:6 n-3 (Binteraction=0.09) and n-3 (Binteraction=0.04) (all p<0.05). Conclusion: CS interacts especially with some circulating PUFA in affecting the individual burden of subclinical atherosclerosis.

Effects of cigarette smoking on the relationship between fatty acids and subclinical atherosclerosis / P.T. Risè, C. Galli, M. Amato, S. Ghezzi, B. Frigerio, S. Castelnuovo, E. Tremoli, C. Sirtori, D. Baldassarre. ((Intervento presentato al 9. convegno ISSFAL - Congress of the International Society for the study of Fatty Acid & Lipids incorporating the 8. International Congress on Essential Fatty acids and Eicosanoids and the 5. PUFA in Maternal and Infant Health meeting tenutosi a Maastricht nel 2010.

Effects of cigarette smoking on the relationship between fatty acids and subclinical atherosclerosis

P.T. Risè;C. Galli;S. Ghezzi;B. Frigerio;S. Castelnuovo;E. Tremoli;C. Sirtori;D. Baldassarre
2010

Abstract

Background: Cigarette smoking (CS) is a determinant of carotid atherosclerosis. Among mechanisms potentially responsible of this effect, e.g activation of extensive peroxidation processes, changes of fatty acid (FA) levels in smokers, especially the reduction of polyunsaturated FA (PUFA) in plasma and tissues, may be involved. Objective: To evaluate whether CS interacts with circulating FA in affecting the individual values of carotid artery intima media thickness (C-IMT). Methods: Plasma FA composition of 32 Smokers and 32 Never-smokers, matched for age, sex and status of hypercholesterolemia was determined by GC analysis after FA transmethylation. C-IMT was measured by Bmode ultrasound. To reach the study objective, correlations between C-IMT and each FA were investigated in both smokers and never-smokers and interactions assessed. Results: As expected, saturated (14:0, 16:0) and monounsaturated (16:1, 18:1, 24:1) FA were higher and PUFA (20:4 n-6 and 22:5, 22:6 n-3) were lower in Smokers than in Never-smokers. The effect of CS on FA was dosedependent for both 20:1 and 18:3 n-3, where a negative correlation with pack-years, an index of global smoking exposure, was found (r=-0.402, p=0.015 and r=-0.346,p=0.039, respectively). Interactions were evaluated after adjustment for fibrate therapy (the unique variable for which the two groups differ) as well as for matching (an adjustment done to take into account that groups were matched). CS significantly interacts with 20:3 n-6 (Binteraction=-0.16), 20:5 n-3 (Binteraction=0.25), 22:5 n-3 (Binteraction=0.43), 22:6 n-3 (Binteraction=0.09) and n-3 (Binteraction=0.04) (all p<0.05). Conclusion: CS interacts especially with some circulating PUFA in affecting the individual burden of subclinical atherosclerosis.
Settore BIO/14 - Farmacologia
Effects of cigarette smoking on the relationship between fatty acids and subclinical atherosclerosis / P.T. Risè, C. Galli, M. Amato, S. Ghezzi, B. Frigerio, S. Castelnuovo, E. Tremoli, C. Sirtori, D. Baldassarre. ((Intervento presentato al 9. convegno ISSFAL - Congress of the International Society for the study of Fatty Acid & Lipids incorporating the 8. International Congress on Essential Fatty acids and Eicosanoids and the 5. PUFA in Maternal and Infant Health meeting tenutosi a Maastricht nel 2010.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/164676
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