A lupin seed γ-conglutin-enriched preparation was tested in a glucose overload trial with both murine models and adult healthy volunteers. The results with rats showed a dose-dependent significant decrease of blood glucose concentration, which confirmed previous findings obtained with the purified protein. Moreover, three test-product doses equivalent to 630, 315, and 157.5 mg γ-conglutin, orally administered 30 min before the carbohydrate supply, showed a relevant hypoglycemic effect in human trials. Insulin concentrations were not significantly affected. The general hematic parameters did not change at all. This is the first report on the glucose-lowering effect of lupin γ-conglutin in human subjects.
|Titolo:||Hypoglycemic effect of lupin seed γ-conglutin in experimental animals and healthy human subjects|
|Parole Chiave:||Antidiabetic; Lupinus albus; Protein extract; Animal trial; Human study|
|Settore Scientifico Disciplinare:||Settore BIO/10 - Biochimica|
Settore AGR/18 - Nutrizione e Alimentazione Animale
|Data di pubblicazione:||ott-2011|
|Digital Object Identifier (DOI):||10.1016/j.fitote.2011.05.007|
|Appare nelle tipologie:||01 - Articolo su periodico|