A lupin seed γ-conglutin-enriched preparation was tested in a glucose overload trial with both murine models and adult healthy volunteers. The results with rats showed a dose-dependent significant decrease of blood glucose concentration, which confirmed previous findings obtained with the purified protein. Moreover, three test-product doses equivalent to 630, 315, and 157.5 mg γ-conglutin, orally administered 30 min before the carbohydrate supply, showed a relevant hypoglycemic effect in human trials. Insulin concentrations were not significantly affected. The general hematic parameters did not change at all. This is the first report on the glucose-lowering effect of lupin γ-conglutin in human subjects.
Hypoglycemic effect of lupin seed γ-conglutin in experimental animals and healthy human subjects / J.C. Bertoglio, M.A. Calvo, J.L. Hancke, R.A. Burgos, A. Riva, P. Morazzoni, C. Ponzone, C. Magni, M.M. Duranti. - In: FITOTERAPIA. - ISSN 1971-551X. - 82:7(2011 Oct), pp. 933-938.
Hypoglycemic effect of lupin seed γ-conglutin in experimental animals and healthy human subjects
C. Magni;M.M. Duranti
2011
Abstract
A lupin seed γ-conglutin-enriched preparation was tested in a glucose overload trial with both murine models and adult healthy volunteers. The results with rats showed a dose-dependent significant decrease of blood glucose concentration, which confirmed previous findings obtained with the purified protein. Moreover, three test-product doses equivalent to 630, 315, and 157.5 mg γ-conglutin, orally administered 30 min before the carbohydrate supply, showed a relevant hypoglycemic effect in human trials. Insulin concentrations were not significantly affected. The general hematic parameters did not change at all. This is the first report on the glucose-lowering effect of lupin γ-conglutin in human subjects.File | Dimensione | Formato | |
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