Seven of 112 hemophiliacs infected with human immunodeficiency virus type-1 (HIV-1) before 1986 through contaminated plasma products are currently healthy, with CD4 T-cell counts above 500 cells/µL, and have never received antiretroviral therapy (long-term nonprogressors [LTNPs]). Seven age and sex-matched hemophiliacs infected in the same period but who have progressive HIV disease (progressors) and one additional slow-progressing individual were also studied. One hundred-fold, 20-fold, and 10-fold lower levels of full-length HIV RNA in plasma, peripheral blood mononuclear cells (PBMCs), and proviral DNA in PBMCs, respectively, were found in LTNPs compared with progressors. Plasma and cell-associated HIV RNA and proviral DNA were lower in LTNPs who tested negative for viral isolation from PBMCs or who were positive only after removal of CD8+ cells. No substantial differences were observed in the in vitro production of chemokines including RANTES, MIP-1alpha , MIP-1beta , MCP-1, and interleukin-8 (IL-8) in supernatants of activated PBMCs or CD8-depleted PBMCs of LTNPs, even when HIV isolation was simultaneously accomplished exclusively after removal of CD8+ cells. Low levels of HIV load and replication in peripheral blood are the strongest correlates of nonprogression in this small number of infected hemophiliacs

Hemophilia and nonprogressing human immunodeficiency virus type 1 infection / E. Vicenzi, P. Bagnarelli, E. Santagostino, S. Ghezzi, M. Alfano, M. S. Sinnone, G. Fabio, L. Turchetto, G. Moretti, A. Lazzarin, A. Mantovani, P. M. Mannucci, M. Clementi, A. Gringeri, G. Poli. - In: BLOOD. - ISSN 0006-4971. - 89:1(1997 Jan), pp. 191-200.

Hemophilia and nonprogressing human immunodeficiency virus type 1 infection

S. Ghezzi;G. Fabio;A. Lazzarin;A. Mantovani;P. M. Mannucci;A. Gringeri
Penultimo
;
1997-01

Abstract

Seven of 112 hemophiliacs infected with human immunodeficiency virus type-1 (HIV-1) before 1986 through contaminated plasma products are currently healthy, with CD4 T-cell counts above 500 cells/µL, and have never received antiretroviral therapy (long-term nonprogressors [LTNPs]). Seven age and sex-matched hemophiliacs infected in the same period but who have progressive HIV disease (progressors) and one additional slow-progressing individual were also studied. One hundred-fold, 20-fold, and 10-fold lower levels of full-length HIV RNA in plasma, peripheral blood mononuclear cells (PBMCs), and proviral DNA in PBMCs, respectively, were found in LTNPs compared with progressors. Plasma and cell-associated HIV RNA and proviral DNA were lower in LTNPs who tested negative for viral isolation from PBMCs or who were positive only after removal of CD8+ cells. No substantial differences were observed in the in vitro production of chemokines including RANTES, MIP-1alpha , MIP-1beta , MCP-1, and interleukin-8 (IL-8) in supernatants of activated PBMCs or CD8-depleted PBMCs of LTNPs, even when HIV isolation was simultaneously accomplished exclusively after removal of CD8+ cells. Low levels of HIV load and replication in peripheral blood are the strongest correlates of nonprogression in this small number of infected hemophiliacs
Hemophilia ; nonprogressing ; human immunodeficiency virus type 1
Settore MED/09 - Medicina Interna
http://bloodjournal.hematologylibrary.org/cgi/content/full/89/1/191
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/157468
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