Motor neuron diseases (MNDs) are a group of neurological disorders that selectively affect motor neurons. There are currently no cures or efficacious treatments for these diseases. In recent years, significant developments in stem cell research have been applied to MNDs, particularly regarding neuroprotection and cell replacement. However, a consistent source of motor neurons for cell replacement is required. Human embryonic stem cells (hESCs) could provide an inexhaustible supply of differentiated cell types, including motor neurons that could be used for MND therapies. Recently, it has been demonstrated that induced pluripotent stem (iPS) cells may serve as an alternative source of motor neurons, since they share ES characteristics, self-renewal, and the potential to differentiate into any somatic cell type. In this review, we discuss several reproducible methods by which hESCs or iPS cells are efficiently isolated and differentiated into functional motor neurons, and possible clinical applications.

Human motor neuron generation from embryonic stem cells and induced pluripotent stem cells / M. Nizzardo, C. Simone, M. Falcone, F. Locatelli, G. Riboldi, G.P. Comi, S. Corti. - In: CELLULAR AND MOLECULAR LIFE SCIENCES. - ISSN 1420-682X. - 67:22(2010 Jul 29), pp. 3837-3847. [10.1007/s00018-010-0463-y]

Human motor neuron generation from embryonic stem cells and induced pluripotent stem cells

M. Nizzardo;C. Simone;M. Falcone;G.P. Comi;S. Corti
2010-07-29

Abstract

Motor neuron diseases (MNDs) are a group of neurological disorders that selectively affect motor neurons. There are currently no cures or efficacious treatments for these diseases. In recent years, significant developments in stem cell research have been applied to MNDs, particularly regarding neuroprotection and cell replacement. However, a consistent source of motor neurons for cell replacement is required. Human embryonic stem cells (hESCs) could provide an inexhaustible supply of differentiated cell types, including motor neurons that could be used for MND therapies. Recently, it has been demonstrated that induced pluripotent stem (iPS) cells may serve as an alternative source of motor neurons, since they share ES characteristics, self-renewal, and the potential to differentiate into any somatic cell type. In this review, we discuss several reproducible methods by which hESCs or iPS cells are efficiently isolated and differentiated into functional motor neurons, and possible clinical applications.
Embryonic stem cell; Induced pluripotent stem cell; Motor neuron; Motor neuron diseases; Protocol
Settore MED/26 - Neurologia
Neuroprotection in Spinal Muscular Atrophy (SMA) using neural stem cells as a therapeutic approach
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/157264
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