Combined quantitative (real-time) polymerase chain reaction and immunohistochemistry were used to evaluate the expression of the minor acute phase protein alpha 1-acid glycoprotein (AGP, orosomucoid) in bovine extrahepatic tissues. AGP was produced mainly in the salivary glands and spleen, whereas minor expression was detected in all other tissues sampled, including lung, lymph nodes, uterus, ovary, kidney and tongue. The findings were consistent with immunohistochemical results. In view of the immunomodulatory and direct antibacterial activity of AGP, its expression in the salivary glands may signal an involvement in the regulation of the local immunity, even in non-pathological conditions.
Lipopolysaccharide-binding protein : local expression in bovine extrahepatic tissues / MD.M. Rahman, C. Lecchi, G. Avallone, P. Roccabianca, P. Sartorelli, F. Ceciliani. - In: VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY. - ISSN 0165-2427. - 137:1/2(2010), pp. 28-35.
|Titolo:||Lipopolysaccharide-binding protein : local expression in bovine extrahepatic tissues|
RAHMAN, MD. MIZANUR (Primo)
LECCHI, CRISTINA (Secondo)
SARTORELLI, PAOLA (Penultimo)
CECILIANI, FABRIZIO (Ultimo)
|Parole Chiave:||Acute phase protein; Bovine; Forestomachs; LBP; Mammary gland|
|Settore Scientifico Disciplinare:||Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria|
|Data di pubblicazione:||2010|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.vetimm.2010.04.006|
|Appare nelle tipologie:||01 - Articolo su periodico|