OBJECTIVE: To evaluate common carotid artery intima-media thickness (CCIMT) and cardiovascular risk factors in HIV-infected adolescents on combination antiretroviral therapy (cART). METHODS: 23 HIV-infected adolescents were matched with 19 healthy subjects by gender, age and body mass index (BMI). CCIMT was measured by Echo-Doppler ultrasound. Bootstrapped multiple linear regression was used to identify potential predictors of CCIMT including HIV status, gender, age, BMI, waist circumference, HDL-cholesterol, LDL- cholesterol, triglycerides, folate, homocysteine, insulin resistance as detected by the homeostasis model assessment, mean blood pressure, and CD36 expression. RESULTS: In the pooled sample, age ranged from 17 to 23 years and BMI between 16.0 and 25.6 kg/m(2). Mean (SD) CCIMT was higher in HIV-infected than in healthy subjects [0.5 (0.1) vs. 0.1 (0.4) mm, p < 0.001]. Higher values of CCIMT were associated with HIV infection (p < 0.001) and male gender (p < 0.001). CCIMT was also associated with the duration of treatment in subjects with the longest cART exposure, i.e. those exposed to a PI-based and/or NNRTI-based regimen plus a single or double NRTI (p = 0.019). CONCLUSION: HIV infection and longer duration of cART are associated with higher CCIMT in adolescents and young adults.

Both HIV-infection and long-term antiretroviral therapy are associated with increased common carotid intima-media thickness in HIV-infected adolescents and young adults / A. Vigano, G. Bedogni, C. Cerini, L. Meroni, V. Giacomet, S. Stucchi, V. Fabiano, S. Coletto, M. Catalano, M. Minola, G.V. Zuccotti. - In: CURRENT HIV RESEARCH. - ISSN 1570-162X. - 8:5(2010 Jul 10), pp. 411-417. [10.2174/157016210791330419]

Both HIV-infection and long-term antiretroviral therapy are associated with increased common carotid intima-media thickness in HIV-infected adolescents and young adults

C. Cerini;V. Giacomet;S. Stucchi;V. Fabiano;S. Coletto;M. Catalano;G.V. Zuccotti
2010

Abstract

OBJECTIVE: To evaluate common carotid artery intima-media thickness (CCIMT) and cardiovascular risk factors in HIV-infected adolescents on combination antiretroviral therapy (cART). METHODS: 23 HIV-infected adolescents were matched with 19 healthy subjects by gender, age and body mass index (BMI). CCIMT was measured by Echo-Doppler ultrasound. Bootstrapped multiple linear regression was used to identify potential predictors of CCIMT including HIV status, gender, age, BMI, waist circumference, HDL-cholesterol, LDL- cholesterol, triglycerides, folate, homocysteine, insulin resistance as detected by the homeostasis model assessment, mean blood pressure, and CD36 expression. RESULTS: In the pooled sample, age ranged from 17 to 23 years and BMI between 16.0 and 25.6 kg/m(2). Mean (SD) CCIMT was higher in HIV-infected than in healthy subjects [0.5 (0.1) vs. 0.1 (0.4) mm, p < 0.001]. Higher values of CCIMT were associated with HIV infection (p < 0.001) and male gender (p < 0.001). CCIMT was also associated with the duration of treatment in subjects with the longest cART exposure, i.e. those exposed to a PI-based and/or NNRTI-based regimen plus a single or double NRTI (p = 0.019). CONCLUSION: HIV infection and longer duration of cART are associated with higher CCIMT in adolescents and young adults.
Antiretroviral therapy; Children; Cross-sectional study; Hiv; Intima-media thickness
Settore MED/09 - Medicina Interna
Settore MED/38 - Pediatria Generale e Specialistica
10-lug-2010
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/141266
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