PEZZOTTA, ALEX
PEZZOTTA, ALEX
Dipartimento di Biotecnologie Mediche e Medicina Traslazionale
HDAC6 AND HDAC8 IN ACUTE MYELOID LEUKEMIA: LESSONS FROM ZEBRAFISH
2024 A. Pezzotta
ADA2 regulates inflammation and hematopoietic stem cell emergence via the A2bR pathway in zebrafish
2024 A. Brix, L. Belleri, A. Pezzotta, E. Pettinato, M. Mazzola, M. Zoccolillo, A. Marozzi, R. Monteiro, F. Del Bene, A. Mortellaro, A. Pistocchi
Hedgehog and HDAC6 in cancers: dissection of dysregulated biological mechanisms and potential therapeutic treatments
2024 A. Pezzotta, L. Brioschi, S. Carbone, G. Galassi, L. Sicuro, M. Alcalay, G. Carullo, G. Campiani, L. Mollica, A. Marozzi, M. Mione, P. Viani, A. Pistocchi
Improving the effects of HDAC8 inhibition by combining the activation of SIRT1 in a zebrafish model of Duchenne muscular dystrophy
2024 A. Pezzotta, S. Carbone, M. Cafora, A. Brix, L. Belleri, M. Giovarelli, L. Lociuro, M. Schiavone, A. Marozzi, F. Del Bene, C. De Palma, A. Pistocchi
Tumor-associated macrophages enhance tumor innervation and spinal cord repair
2024 S. Dolci, L. Mannino, A. Campanelli, E. Rossi, E. Bottani, F. Ciarpella, I. Karkossa, E. Setten, B. Savino, G. Pruonto, N. Piazza, S. Gianoli, A. Amenta, G. Busetto, A. Pezzotta, M. Di Chio, A. Castagna, N. Martinelli, I. Barone, F. Boschi, A. Doherty, M. Teresa Scupoli, C. Cavallini, G. Malpeli, Z. Malik, L. Sagripanti, V. Silani, P. Cristofori, E. Scanziani, M. Sandri, A. Pistocchi, P. Bossolasco, M. Endrizzi, K. Schubert, G. Francesco Fumagalli, M. Locati, F. Bifari, I. Decimo
Nanoplastic impact on bone microenvironment: A snapshot from murine bone cells
2024 D. Giannandrea, M. Parolini, V. Citro, B. De Felice, A. Pezzotta, N. Abazari, N. Platonova, M. Sugni, M. Chiu, A. Villa, E. Lesma, R. Chiaramonte, L. Casati
Development of Epigenetic Modifiers with Therapeutic Potential in FMS-Related Tyrosine Kinase 3/Internal Tandem Duplication (FLT3/ITD) Acute Myeloid Leukemia and Other Blood Malignancies
2024 G. Carullo, S. Rossi, V. Giudice, A. Pezzotta, U. Chianese, P. Scala, S. Carbone, A. Fontana, G. Panzeca, S. Pasquini, C. Contri, S. Gemma, A. Ramunno, S. Saponara, F. Galvani, A. Lodola, M. Mor, R. Benedetti, C. Selleri, K. Varani, S. Butini, L. Altucci, F. Vincenzi, A. Pistocchi, G. Campiani
HDAC6 inhibition decreases leukemic stem cell expansion driven by Hedgehog hyperactivation by restoring primary ciliogenesis
2023 A. Pezzotta, I. Gentile, D. Genovese, M. Totaro, C. Battaglia, A. Leung, M. Fumagalli, M. Parma, G. Cazzaniga, G. Fazio, M. Alcalaym, A. Marozzi, A. Pistocchi
Combined Inhibition of Hedgehog and HDAC6: In Vitro and In Vivo Studies Reveal a New Role for Lysosomal Stress in Reducing Glioblastoma Cell Viability
2023 A. Pezzotta, L. Brioschi, S. Carbone, B. Mazzoleni, V. Bontempi, F. Monastra, L. Mauri, A. Marozzi, M. Mione, A. Pistocchi, P. Viani
Lymphatic Defects in Zebrafish sox18 Mutants Are Exacerbated by Perturbed VEGFC Signaling, While Masked by Elevated sox7 Expression
2023 S. Moleri, S. Mercurio, A. Pezzotta, D. D’Angelo, A. Brix, A. Plebani, G. Lini, M. Di Fuorti, M. Beltrame
Targeting Hedgehog and HDAC6 in acute myeloid leukemia in in vitro and zebrafish models
2022 A. Pezzotta, I. Gentile, D. Genovese, M. Totaro, C. Battaglia, A. Leung, M. Fumagalli, M. Parma, M. Alcalay, A. Marozzi, A. Pistocchi
HEDGEHOG/HDAC6 INHIBITION AND CHEMOTHERAPY: ASSESSMENT OF NEW DRUG COMBINATION IN ACUTE MYELOID LEUKEMIA
2022 A. Pezzotta
HDAC6 inhibition decreases leukemic stem cell expansion driven by Hedgehog hyperactivation by restoring primary ciliogenesis
2022 A. Pezzotta, I. Gentile, D. Genovese, M.G. Totaro, C. Battaglia, A.Y. Leung, M. Fumagalli, M. Parma, G. Cazzaniga, G. Fazio, M. Alcalay, A. Marozzi, A. Pistocchi
Identification of a new candidate gene in the insurgence of leukodystrophies
2022 A. Pezzotta, M. Spreafico, S. Magri, F. Balistreri, D. Di Bella, C. Gellera, E. Salsano, F. Taroni, A. Pistocchi
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability
2022 S. Federico, T. Khan, A. Fontana, S. Brogi, R. Benedetti, F. Sarno, G. Carullo, A. Pezzotta, A.P. Saraswati, E. Passaro, L. Pozzetti, A. Papa, N. Relitti, S. Gemma, S. Butini, A. Pistocchi, A. Ramunno, F. Vincenzi, K. Varani, V. Tatangelo, L. Patrussi, C.T. Baldari, S. Saponara, B. Gorelli, S. Lamponi, M. Valoti, F. Saccoccia, M. Giannaccari, G. Ruberti, D. Herp, M. Jung, L. Altucci, G. Campiani
A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis
2021 D. Pradella, G. Deflorian, A. Pezzotta, A. Di Matteo, E. Belloni, D. Campolungo, A. Paradisi, M. Bugatti, W. Vermi, M. Campioni, A. Chiapparino, L. Scietti, F. Forneris, C. Giampietro, N. Volf, M. Rehman, S. Zacchigna, M.P. Paronetto, A. Pistocchi, A. Eichmann, P. Mehlen, C. Ghigna
Dysregulation of NIPBL leads to impaired RUNX1 expression and hematopoietic defects
2020 M. Mazzola, A. Pezzotta, E. Bresciani, L. Ferrari, A. Rigamonti, M. Pelleri, C. Saitta, G. Gaudenzi, G. Fazio, M. Parma, M. Fumagalli, A. Biondi, G. Cazzaniga, A. Marozzi, A. PIstocchi
Enigmatic ladies of the rings : how cohesin dysfunction affects myeloid neoplasms insurgence
2019 A. Pezzotta, M. Mazzola, M. Spreafico, A. Marozzi, A. Pistocchi
HDAC8 regulates canonical Wnt pathway to promote differentiation in skeletal muscles
2019 L. Ferrari, C. Bragato, L. Brioschi, M. Spreafico, S. Esposito, A. Pezzotta, F. Pizzetti, A. Moreno-Fortuny, G. Bellipanni, A. Giordano, P. Riva, F. Frabetti, P. Viani, G. Cossu, M. Mora, A. Marozzi, A. Pistocchi
NIPBL: a new player in myeloid cells differentiation
2019 M. Mazzola, G. Deflorian, A. Pezzotta, L. Ferrari, G. Fazio, E. Bresciani, C. Saitta, L. Ferrari, M. Fumagalli, M. Parma, F. Marasca, B. Bodega, P. Riva, F. Cotelli, A. Biondi, A. Marozzi, G. Cazzaniga, A. Pistocchi