SANTANGELO, SERENA
SANTANGELO, SERENA
Dipartimento di Biotecnologie Mediche e Medicina Traslazionale
INDUCED PLURIPOTENT STEM CELLS (IPSC) TO STUDY PATHOMECHANISMS ASSOCIATED TO AMYOTROPHIC LATERAL SCLEROSIS (ALS)
2023 S. Santangelo
Generation of five induced pluripotent stem cells lines from four members of the same family carrying a C9orf72 repeat expansion and one wild-type member
2023 C. Lattuada, S. Santangelo, S. Peverelli, P. Mcgoldrick, E. Rogaeva, L. Zinman, G. Haase, V. Géli, V. Silani, J. Robertson, A. Ratti, P. Bossolasco
U1 snRNA as a novel RNA-based therapeutic approach to modulate C9ORF72 pathology in patient-derived iPSC-motoneurons
2023 S. Invernizzi, S. Santangelo, E. Bussani, G. Romano, C. Colombrita, V. Casiraghi, M. Nice Sorce, P. Bossolasco, V. Silani, F. Pagani, A. Ratti
Human motor neurons derived from induced pluripotent stem cells are susceptible to SARS-CoV-2 infection
2023 G. Cappelletti, C. Colombrita, F. Limanaqi, S. Invernizzi, M. Garziano, C. Vanetti, C. Moscheni, S. Santangelo, S. Zecchini, D. Trabattoni, V. Silani, M. Clerici, A. Ratti, M. Biasin
Molecular mechanisms in KIF5A-related neurodegeneration
2023 M. Cozzi, B. Tedesco, V. Ferrari, E. Casarotto, M. Chierichetti, P. Pramaggiore, M. Piccolella, M. Galbiati, P. Rusmini, V. Crippa, C. Gellera, S. Magri, S. Santangelo, A. Ratti, R. Cristofani, F. Taroni, A. Poletti
Rapamycin reverts TDP-43 splicing defects and mislocalization in human in vitro models of TDP-43 proteinopathy
2023 V. Casiraghi, C. Colombrita, S. Santangelo, S. Invernizzi, M.N. Sorce, P. Bossolasco, V. Silani, A. Ratti
Generation of an iPSC line from a patient with spastic paraplegia type 10 carrying a novel mutation in KIF5A gene
2023 S. Santangelo, P. Bossolasco, S. Magri, C. Colombrita, S. Invernizzi, C. Gellera, L. Nanetti, D. Di Bella, V. Silani, F. Taroni, A. Ratti
One gene, many phenotypes: investigating KIF5A-linked neurodegeneration mechanisms
2022 M. Cozzi, B. Tedesco, R.M. Cristofani, V. Ferrari, E. Casarotto, M. Chierichetti, P. Pramaggiore, M. Piccolella, M. Galbiati, P. Rusmini, V. Crippa, C. Gellera, S. Magri, S. Santangelo, A. Ratti, F. Taroni, A. Poletti
Insights into the neurodegenerative mechanisms associated with KIF5A mutations
2022 M. Cozzi, B. Tedesco, R.M. Cristofani, V. Ferrari, E. Casarotto, M. Chierichetti, F. Mina, P. Pramaggiore, M. Piccolella, M. Galbiati, P. Rusmini, V. Crippa, C. Gellera, S. Magri, S. Santangelo, A. Ratti, F. Taroni, A. Poletti
Investigating the molecular mechanisms involved in KIF5A-related neurodegeneration
2022 M. Cozzi, B. Tedesco, R.M. Cristofani, V. Ferrari, E. Casarotto, M. Chierichetti, F. Mina, M. Piccolella, M. Galbiati, P. Rusmini, V. Crippa, C. Gellera, S. Magri, S. Santangelo, A. Ratti, F. Taroni, A. Poletti
Analysis of the pathogenetic mechanisms involved in KIF5A-related neurodegenerative disorders
2022 M. Cozzi, B. Tedesco, R.M. Cristofani, V. Ferrari, E. Casarotto, M. Chierichetti, F. Mina, G. Avella, M. Piccolella, M. Galbiati, P. Rusmini, V. Crippa, C. Gellera, S. Magri, S. Santangelo, A. Ratti, F. Taroni, A. Poletti
Human in vitro models of TDP-43 proteinopathy for drug screening approaches
2022 V. Casiraghi, C. Colombrita, S. Santangelo, S. Invernizzi, M.N. Sorce, V. Silani, A. Ratti
U1 snRNA as a novel RNA-based therapeutic approach to modulate C9ORF72 pathology in patient-derived iPSC-motoneurons
2022 S. Santangelo, C. Colombrita, E. Bussani, S. Invernizzi, M. Nice Sorce, V. Casiraghi, C. Lattuada, P. Bossolasco, V. Silani, F. Pagani, A. Ratti
Modeling a novel N-terminal mutation of KIF5A gene in patient-derived iPSC-motoneurons
2022 S. Santangelo, P. Bossolasco, C. Fallini, S. Magri, M. Bertocchi, S. Invernizzi, D. Di Bella, D. Bardelli, C. Colombrita, V. Silani, F. Taroni, A. Ratti
Modelling ALS disease by 2D and 3D in vitro models of patient-derived iPSC
2022 P. Bossolasco, S. Santangelo, L. Lattuada, M.N. Sorce, C. Colombrita, V. Casiraghi, S. Peverelli, A. Ratti, V. Silani
Characterization of iPSC-motoneurons from a HSP patient with a novel mutation in KIF5A N-terminal region Characterization of iPSCmotoneurons from a HSP patient with a novel mutation in KIF5A N-terminal region
2022 S. Santangelo, P. Bossolasco, C. Fallini, S. Magri, M. Bertocchi, S. Invernizzi, D. Di Bella, D. Bardelli, C. Colombrita, V. Silani, F. Taroni, A. Ratti
Rapamycin reverts TDP-43 splicing defects and mislocalization in human in vitro models of TDP-43 proteinopathy
2022 V. Casiraghi, C. Colombrita, S. Santangelo, I. Milone, M.N. Sorce, V. Silani, A. Ratti
Rapamycin reverts TDP-43 splicing defects and mislocalization in human in vitro models of TDP-43 proteinopathy
2022 V. Casiraghi, C. Colombrita, S. Santangelo, I. Milone, M.N. Sorce, V. Silani, A. Ratti
Rapamycin reverts TDP-43 splicing defects and oxidative stress-induced alterations in a human in vitro model of TDP-43 proteinopathy
2022 V. Casiraghi, C. Colombrita, S. Santangelo, I. Milone, M.N. Sorce, V. Silani, A. Ratti
Effect of NEK1/C9ORF72 double mutation on DNA damage response in patient-derived neural stem cells
2021 S. Santangelo, C. Colombrita, P. Bossolasco, S. Peverelli, S. Invernizzi, A. Brusati, V. Gumina, D. Bardelli, N. Ticozzi, V. Silani, A. Ratti