We studied POLG1 in 140 UK patients with idiopathic Parkinson disease (PD) and 279 Italian patients with PD and compared them to a UK control group (n = 207) and an Italian control group (n = 285). Our observations do not support a role for common POLG1 genetic variants in PD and indicate that dominant POLG1 mutations are a rare cause of parkinsonism in the general population.
POLG1 in idiopathic Parkinson disease / W. Tiangyou, G. Hudson, D. Ghezzi, G. Ferrari, M. Zeviani, D.J. Burn, P.F. Chinnery. - In: NEUROLOGY. - ISSN 0028-3878. - 67:9(2006), pp. 1698-1700. [10.1212/01.wnl.0000238963.07425.d5]
POLG1 in idiopathic Parkinson disease
D. Ghezzi;
2006
Abstract
We studied POLG1 in 140 UK patients with idiopathic Parkinson disease (PD) and 279 Italian patients with PD and compared them to a UK control group (n = 207) and an Italian control group (n = 285). Our observations do not support a role for common POLG1 genetic variants in PD and indicate that dominant POLG1 mutations are a rare cause of parkinsonism in the general population.
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