HLA allelic distribution was analysed in a cohort of 96 Northern Italian subjects (53M/43F) (mean age 59.9 ± 13.3 years) from Lombardy who developed COVID-19 during the first two pandemic waves to investigate possible correlations between HLA molecules and disease severity. An important role of HLA-B and HLA-C loci in modulating the clinical severity of COVID-19 disease was identified. In particular, the HLA-B07 supertype was observed to be associated with a significant risk for severe disease; conversely, the HLA-B27 supertype and C*12:02 allele played a protective role as they were associated with milder disease. These associations were confirmed after applying a multinomial regression analysis to adjust the correlation for age, gender and comorbidities with COVID-19 severity. Though the power of results is limited by the small sample size, data herein contribute to shedding light on the role played by genetic background in COVID-19 infection.
HLA Allele Frequencies and Association with Severity of COVID-19 Infection in Northern Italian Patients / F.R. Guerini, E. Bolognesi, A. Lax, L.N.C. Bianchi, A. Caronni, M. Zanzottera, C. Agliardi, M.P. Albergoni, P.I. Banfi, J. Navarro, M. Clerici. - In: CELLS. - ISSN 2073-4409. - 11:11(2022), pp. 1792.1-1792.8. [10.3390/cells11111792]
HLA Allele Frequencies and Association with Severity of COVID-19 Infection in Northern Italian Patients
F.R. GueriniPrimo
;A. Caronni;M. ClericiUltimo
2022
Abstract
HLA allelic distribution was analysed in a cohort of 96 Northern Italian subjects (53M/43F) (mean age 59.9 ± 13.3 years) from Lombardy who developed COVID-19 during the first two pandemic waves to investigate possible correlations between HLA molecules and disease severity. An important role of HLA-B and HLA-C loci in modulating the clinical severity of COVID-19 disease was identified. In particular, the HLA-B07 supertype was observed to be associated with a significant risk for severe disease; conversely, the HLA-B27 supertype and C*12:02 allele played a protective role as they were associated with milder disease. These associations were confirmed after applying a multinomial regression analysis to adjust the correlation for age, gender and comorbidities with COVID-19 severity. Though the power of results is limited by the small sample size, data herein contribute to shedding light on the role played by genetic background in COVID-19 infection.File | Dimensione | Formato | |
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