In our functional dissection of the CD33 Alzheimer's disease susceptibility locus, we found that the rs3865444(C) risk allele was associated with greater cell surface expression of CD33 in the monocytes ( t(50) = 10.06, P-joint = 1.3 x 10(-13)) of young and older individuals. It was also associated with diminished internalization of amyloid-beta 42 peptide, accumulation of neuritic amyloid pathology and fibrillar amyloid on in vivo imaging, and increased numbers of activated human microglia.
CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology / E.M. Bradshaw, L.B. Chibnik, B.T. Keenan, L. Ottoboni, T. Raj, A. Tang, L.L. Rosenkrantz, S. Imboywa, M. Lee, A. Von Korff, M.C. Morris, D.A. Evans, K. Johnson, R.A. Sperling, J.A. Schneider, D.A. Bennett, P.L. De Jager. - In: NATURE NEUROSCIENCE. - ISSN 1097-6256. - 16:7(2013 Jul), pp. 848-850. [10.1038/nn.3435]
CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology
L. Ottoboni;K. Johnson;
2013
Abstract
In our functional dissection of the CD33 Alzheimer's disease susceptibility locus, we found that the rs3865444(C) risk allele was associated with greater cell surface expression of CD33 in the monocytes ( t(50) = 10.06, P-joint = 1.3 x 10(-13)) of young and older individuals. It was also associated with diminished internalization of amyloid-beta 42 peptide, accumulation of neuritic amyloid pathology and fibrillar amyloid on in vivo imaging, and increased numbers of activated human microglia.
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