Neurogenesis persists in the adult brain of mammals in the subventricular zone (SVZ) of the lateral ventricles and in the subgranular zone (SGZ) of the dentate gyms (DG). The complex interactions between intrinsic and extrinsic signals provided by cells in the niche but also from distant sources regulate the fate of neural stem/progenitor cells (NPCs) in these sites. This fine regulation is perturbed in aging and in pathological conditions leading to a different NPC behavior, tailored to the specific physio-pathological features. Indeed, NPCs exert in physiological and pathological conditions important neurogenic and non-neurogenic regulatory functions and participate in maintaining and protecting brain tissue homeostasis. In this review, we discuss intrinsic and extrinsic signals that regulate NPC activation and NPC functional role in various homeostatic and non-homeostatic conditions.

Endogenous neural precursor cells in health and disease / M. Bacigaluppi, G. Sferruzza, E. Butti, L. Ottoboni, G. Martino. - In: BRAIN RESEARCH. - ISSN 1872-6240. - 1730:(2020 Mar 01), pp. 146619.1-146619.18. [10.1016/j.brainres.2019.146619]

Endogenous neural precursor cells in health and disease

L. Ottoboni
Penultimo
;
2020

Abstract

Neurogenesis persists in the adult brain of mammals in the subventricular zone (SVZ) of the lateral ventricles and in the subgranular zone (SGZ) of the dentate gyms (DG). The complex interactions between intrinsic and extrinsic signals provided by cells in the niche but also from distant sources regulate the fate of neural stem/progenitor cells (NPCs) in these sites. This fine regulation is perturbed in aging and in pathological conditions leading to a different NPC behavior, tailored to the specific physio-pathological features. Indeed, NPCs exert in physiological and pathological conditions important neurogenic and non-neurogenic regulatory functions and participate in maintaining and protecting brain tissue homeostasis. In this review, we discuss intrinsic and extrinsic signals that regulate NPC activation and NPC functional role in various homeostatic and non-homeostatic conditions.
Aging; Bystander effect; Neural stem cells; Non neurogenesis; Role of neurogenesis; Subventricular zone; Therapeutic plasticity
Settore MED/50 - Scienze Tecniche Mediche Applicate
Settore MED/26 - Neurologia
1-mar-2020
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/968238
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