The members of the International Union of Pharmacol. (IUPHAR) Subcommittee for P2Y receptor nomenclature and classification carefully examd. the report of Inbe et al. (2004), entitled "Identification and characterization of a cell-surface receptor, P2Y15 for AMP and adenosine" and of He et al. (2004), entitled "Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors" to establish whether or not to accept GPR80/GPR99 as the P2Y15 receptor. It was concluded that the results of Inbe et al. were more likely to be due to high levels of expression of endogenous adenosine receptors in the clone of HEK293 cells expressing GPR80/GPR99, and/or to heterodimer formation or another artifact. Thus, the P2Y Receptor Nomenclature Subcommittee has decided that GPR80/GPR99 is not a P2Y receptor for adenosine, AMP or other nucleotides, but instead is activated by citric acid cycle intermediates. To avoid confusion in P2Y receptor Nomenclature, the Subcommittee recommends that the name P2Y15 should not be used when referring to this receptor.
|Titolo:||The recently deorphanized GPR80 (GPR99) proposed to be the P2Y15 receptor is not a genuine P2Y receptor|
ABBRACCHIO, MARIA PIA (Primo)
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||2005|
|Digital Object Identifier (DOI):||10.1016/j.tips.2004.10.010|
|Appare nelle tipologie:||01 - Articolo su periodico|