Lamina-associated domains (LADs) are large heterochromatic regions that are positioned at the nuclear lamina (NL). A major question is how LAD-NL interactions are mediated and controlled. Here, we review recent progress in the search for molecular tethers and looseners of LADs and we discuss the link between LAD-NL tethering, transcription regulation, and genome replication. We also provide a brief summary of technological advances that may uncover new aspects of LAD biology.

Lamina-associated domains: Tethers and looseners / S.G. Manzo, L. Dauban, B. van Steensel. - In: CURRENT OPINION IN CELL BIOLOGY. - ISSN 0955-0674. - 74:(2022 Feb), pp. 80-87. [10.1016/j.ceb.2022.01.004]

Lamina-associated domains: Tethers and looseners

S.G. Manzo
Co-primo
;
2022

Abstract

Lamina-associated domains (LADs) are large heterochromatic regions that are positioned at the nuclear lamina (NL). A major question is how LAD-NL interactions are mediated and controlled. Here, we review recent progress in the search for molecular tethers and looseners of LADs and we discuss the link between LAD-NL tethering, transcription regulation, and genome replication. We also provide a brief summary of technological advances that may uncover new aspects of LAD biology.
English
Settore BIO/11 - Biologia Molecolare
Review essay
Sì, ma tipo non specificato
Pubblicazione scientifica
feb-2022
18-feb-2022
Elsevier; CURRENT BIOLOGY LTD
74
80
87
8
Pubblicato
Periodico con rilevanza internazionale
pubmed
scopus
crossref
wos
datacite
Aderisco
info:eu-repo/semantics/article
Lamina-associated domains: Tethers and looseners / S.G. Manzo, L. Dauban, B. van Steensel. - In: CURRENT OPINION IN CELL BIOLOGY. - ISSN 0955-0674. - 74:(2022 Feb), pp. 80-87. [10.1016/j.ceb.2022.01.004]
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Article (author)
Periodico con Impact Factor
S.G. Manzo, L. Dauban, B. van Steensel
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/956625
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