Lamina-associated domains (LADs) are large heterochromatic regions that are positioned at the nuclear lamina (NL). A major question is how LAD-NL interactions are mediated and controlled. Here, we review recent progress in the search for molecular tethers and looseners of LADs and we discuss the link between LAD-NL tethering, transcription regulation, and genome replication. We also provide a brief summary of technological advances that may uncover new aspects of LAD biology.
Lamina-associated domains: Tethers and looseners / S.G. Manzo, L. Dauban, B. van Steensel. - In: CURRENT OPINION IN CELL BIOLOGY. - ISSN 0955-0674. - 74:(2022 Feb), pp. 80-87. [10.1016/j.ceb.2022.01.004]
Lamina-associated domains: Tethers and looseners
S.G. ManzoCo-primo
;
2022
Abstract
Lamina-associated domains (LADs) are large heterochromatic regions that are positioned at the nuclear lamina (NL). A major question is how LAD-NL interactions are mediated and controlled. Here, we review recent progress in the search for molecular tethers and looseners of LADs and we discuss the link between LAD-NL tethering, transcription regulation, and genome replication. We also provide a brief summary of technological advances that may uncover new aspects of LAD biology.
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