In recent years, the existing relationship between excess overweight and central precocious puberty (CPP) has been reported, especially in girls. Different nutritional choices have been associated with different patterns of puberty. In particular, the involvement of altered biochemical and neuroen- docrine pathways and a proinflammatory status has been described in connection with a high-fat diet (HFD). In this narrative review, we present an overview on the relationship between obesity and precocious pubertal development, focusing on the role of HFDs as a contributor to activating the hypothalamus–pituitary–gonadal axis. Although evidence is scarce and studies limited, especially in the paediatric field, the harm of HFDs on PP is a relevant problem that cannot be ignored. Increased knowledge about HFD effects will be useful in developing strategies preventing precocious puberty in children with obesity. Promoting HFD-avoiding behavior may be useful in preserving children’s physiological development and protecting reproductive health. Controlling HFDs may represent a target for policy action to improve global health.

Links between Childhood Obesity, High-Fat Diet, and Central Precocious Puberty / V. Calcaterra, V.C. Magenes, C. Hruby, F. Siccardo, A. Mari, E. Cordaro, V. Fabiano, G.V. Zuccotti. - In: CHILDREN. - ISSN 2227-9067. - 10:(2023), pp. 241.1-241.20. [10.3390/children10020241]

Links between Childhood Obesity, High-Fat Diet, and Central Precocious Puberty

V.C. Magenes
Secondo
;
C. Hruby;F. Siccardo;A. Mari;V. Fabiano
Penultimo
;
G.V. Zuccotti
Ultimo
2023

Abstract

In recent years, the existing relationship between excess overweight and central precocious puberty (CPP) has been reported, especially in girls. Different nutritional choices have been associated with different patterns of puberty. In particular, the involvement of altered biochemical and neuroen- docrine pathways and a proinflammatory status has been described in connection with a high-fat diet (HFD). In this narrative review, we present an overview on the relationship between obesity and precocious pubertal development, focusing on the role of HFDs as a contributor to activating the hypothalamus–pituitary–gonadal axis. Although evidence is scarce and studies limited, especially in the paediatric field, the harm of HFDs on PP is a relevant problem that cannot be ignored. Increased knowledge about HFD effects will be useful in developing strategies preventing precocious puberty in children with obesity. Promoting HFD-avoiding behavior may be useful in preserving children’s physiological development and protecting reproductive health. Controlling HFDs may represent a target for policy action to improve global health.
childhood obesity; high-fat diet; central precocious puberty; pediatrics; children
Settore MED/38 - Pediatria Generale e Specialistica
Settore MED/13 - Endocrinologia
2023
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/952612
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