5-Phenyl-furan-2-carboxylic acids have emerged as a new, promising class of antimycobacterial agents that have the ability to interfere with iron homeostasis. Considering the lack of structural data on these compounds, we analyzed the crystal of a fluorinated ester derivative of 5-(4-nitrophenyl)furan-2-carboxylic acid, one of the most potent candidates in the series. Here, we describe the preparation of methyl 5-(2-fluoro-4-nitrophenyl)furan-2-carboxylate (1) and its analysis by 1H-NMR, 13C-NMR, HRMS, and SC-XRD.
Methyl 5-(2-Fluoro-4-nitrophenyl)furan-2-carboxylate / M. Mori, A. Tresoldi, G. Cazzaniga, F. Meneghetti, S. Villa. - In: MOLBANK. - ISSN 1422-8599. - 2022:(2022 Nov 12), pp. M1492.1-M1492.10. [10.3390/M1492]
Methyl 5-(2-Fluoro-4-nitrophenyl)furan-2-carboxylate
M. MoriPrimo
;G. Cazzaniga;F. Meneghetti
Penultimo
;S. VillaUltimo
2022
Abstract
5-Phenyl-furan-2-carboxylic acids have emerged as a new, promising class of antimycobacterial agents that have the ability to interfere with iron homeostasis. Considering the lack of structural data on these compounds, we analyzed the crystal of a fluorinated ester derivative of 5-(4-nitrophenyl)furan-2-carboxylic acid, one of the most potent candidates in the series. Here, we describe the preparation of methyl 5-(2-fluoro-4-nitrophenyl)furan-2-carboxylate (1) and its analysis by 1H-NMR, 13C-NMR, HRMS, and SC-XRD.
| File | Dimensione | Formato | |
|---|---|---|---|
|
molbank-2022-M1492-v2.pdf
accesso aperto
Tipologia:
Publisher's version/PDF
Dimensione
2.48 MB
Formato
Adobe PDF
|
2.48 MB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
