While RNA editing by A-to-I deamination is a requisite for neuronal function in humans, it is under-investigated in single cells. Here we fill this gap by analyzing RNA editing profiles of single cells from the brain cortex of living human subjects. We show that RNA editing levels per cell are bimodally distributed and distinguish between major brain cell types, thus providing new insights into neuronal dynamics.

Single-cell transcriptomics reveals specific {RNA} editing signatures in the human brain / E. Picardi, D.S. Horner, G. Pesole. - In: RNA. - ISSN 1355-8382. - 23:6(2017), pp. 860-865. [10.1261/rna.058271.116]

Single-cell transcriptomics reveals specific {RNA} editing signatures in the human brain

D.S. Horner
Secondo
Methodology
;
G. Pesole
Ultimo
Project Administration
2017

Abstract

While RNA editing by A-to-I deamination is a requisite for neuronal function in humans, it is under-investigated in single cells. Here we fill this gap by analyzing RNA editing profiles of single cells from the brain cortex of living human subjects. We show that RNA editing levels per cell are bimodally distributed and distinguish between major brain cell types, thus providing new insights into neuronal dynamics.
No
English
RNA editing; single cell; RNA-seq; transcriptome
Settore BIO/11 - Biologia Molecolare
Articolo
Esperti anonimi
Pubblicazione scientifica
2017
RNA
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
23
6
860
865
6
Pubblicato
Periodico con rilevanza internazionale
orcid
scopus
pubmed
crossref
wos
datacite
Aderisco
info:eu-repo/semantics/article
Single-cell transcriptomics reveals specific {RNA} editing signatures in the human brain / E. Picardi, D.S. Horner, G. Pesole. - In: RNA. - ISSN 1355-8382. - 23:6(2017), pp. 860-865. [10.1261/rna.058271.116]
open
Prodotti della ricerca::01 - Articolo su periodico
3
262
Article (author)
Periodico con Impact Factor
E. Picardi, D.S. Horner, G. Pesole
File in questo prodotto:
File Dimensione Formato  
RNA-2017-Picardi-860-5.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 558.83 kB
Formato Adobe PDF
558.83 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/939526
Citazioni
  • ???jsp.display-item.citation.pmc??? 28
  • Scopus 57
  • ???jsp.display-item.citation.isi??? 55
social impact