While RNA editing by A-to-I deamination is a requisite for neuronal function in humans, it is under-investigated in single cells. Here we fill this gap by analyzing RNA editing profiles of single cells from the brain cortex of living human subjects. We show that RNA editing levels per cell are bimodally distributed and distinguish between major brain cell types, thus providing new insights into neuronal dynamics.
Single-cell transcriptomics reveals specific {RNA} editing signatures in the human brain / E. Picardi, D.S. Horner, G. Pesole. - In: RNA. - ISSN 1355-8382. - 23:6(2017), pp. 860-865. [10.1261/rna.058271.116]
Single-cell transcriptomics reveals specific {RNA} editing signatures in the human brain
D.S. HornerSecondo
Methodology
;G. Pesole
Ultimo
Project Administration
2017
Abstract
While RNA editing by A-to-I deamination is a requisite for neuronal function in humans, it is under-investigated in single cells. Here we fill this gap by analyzing RNA editing profiles of single cells from the brain cortex of living human subjects. We show that RNA editing levels per cell are bimodally distributed and distinguish between major brain cell types, thus providing new insights into neuronal dynamics.File in questo prodotto:
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