Simple Summary The efficacy and safety of oxaliplatin-based regimens in late-care settings have been poorly reported. In 119 mCRC patients, the oxaliplatin retreatment response rate (RR) was 21.6%. The median progression-free survival was 5.1 months. A total of 34/119 (28.6%) discontinued treatments were due to toxicities. Oxaliplatin retreatment produced further RR, but one-third of patients discontinued treatment due to adverse events. Thus, translational studies that improve patient selections are warranted. Background: oxaliplatin with fluoropyrimidine is a "mainstay" regarding the upfront treatment of metastatic colorectal cancer (mCRC). In contrast, the efficacy and safety of oxaliplatin-based regimens in late-care settings have been poorly reported. Methods: we identified a real-world mCRC patient cohort who were re-treated with oxaliplatin, and in which clinicopathological features were retrospectively analyzed to identify efficacy-predictive determinants (RETROX-CRC study). Results: of 2606 patients, 119 fulfilled the eligibility criteria. Oxaliplatin retreatment response rate (RR) and disease control rate (DCR) were 21.6% (CI 14.4-31.0%), and 57.8% (CI 47.7-67.4). A trend towards better RR and DCR was observed among patients who had first oxaliplatin in an adjuvant setting; a poorer outcome was observed if two or more intervening treatments were delivered. Median progression-free survival (PFS) was 5.1 months (95%CI 4.3-6.1), reducing to 4.0 months (95%CI 3.07-5.13) if oxaliplatin was readministered beyond third-line (HR 2.02; 1.25-3.25; p = 0.004). Safety data were retrieved in 65 patients (54.6%); 18.5% (12/65) and 7.7% (5/65) had G3-4 toxicities. Toxicities led to discontinuation in 34/119 (28.6%). Conclusions: oxaliplatin retreatment produced further RR in around one-fifth of patients and DCR 57.8%. Efficacy decreased in more pre-treated patients and around one-third of patients discontinued treatment due to adverse events. Translational studies improving patient selection are warranted.

Efficacy of Retreatment with Oxaliplatin-Based Regimens in Metastatic Colorectal Cancer Patients: The RETROX-CRC Retrospective Study / A. Amatu, G. Mauri, F.M. Tosi, K. Bencardino, E. Bonazzina, V. Gori, L. Ruggieri, S. Arena, A. Bardelli, S. Marsoni, S. Siena, A. SARTORE BIANCHI. - In: CANCERS. - ISSN 2072-6694. - 14:5(2022), pp. 1197.1-1197.12. [10.3390/cancers14051197]

Efficacy of Retreatment with Oxaliplatin-Based Regimens in Metastatic Colorectal Cancer Patients: The RETROX-CRC Retrospective Study

G. Mauri
Co-primo
;
F.M. Tosi;V. Gori;L. Ruggieri;S. Siena
Penultimo
;
A. SARTORE BIANCHI
Ultimo
2022

Abstract

Simple Summary The efficacy and safety of oxaliplatin-based regimens in late-care settings have been poorly reported. In 119 mCRC patients, the oxaliplatin retreatment response rate (RR) was 21.6%. The median progression-free survival was 5.1 months. A total of 34/119 (28.6%) discontinued treatments were due to toxicities. Oxaliplatin retreatment produced further RR, but one-third of patients discontinued treatment due to adverse events. Thus, translational studies that improve patient selections are warranted. Background: oxaliplatin with fluoropyrimidine is a "mainstay" regarding the upfront treatment of metastatic colorectal cancer (mCRC). In contrast, the efficacy and safety of oxaliplatin-based regimens in late-care settings have been poorly reported. Methods: we identified a real-world mCRC patient cohort who were re-treated with oxaliplatin, and in which clinicopathological features were retrospectively analyzed to identify efficacy-predictive determinants (RETROX-CRC study). Results: of 2606 patients, 119 fulfilled the eligibility criteria. Oxaliplatin retreatment response rate (RR) and disease control rate (DCR) were 21.6% (CI 14.4-31.0%), and 57.8% (CI 47.7-67.4). A trend towards better RR and DCR was observed among patients who had first oxaliplatin in an adjuvant setting; a poorer outcome was observed if two or more intervening treatments were delivered. Median progression-free survival (PFS) was 5.1 months (95%CI 4.3-6.1), reducing to 4.0 months (95%CI 3.07-5.13) if oxaliplatin was readministered beyond third-line (HR 2.02; 1.25-3.25; p = 0.004). Safety data were retrieved in 65 patients (54.6%); 18.5% (12/65) and 7.7% (5/65) had G3-4 toxicities. Toxicities led to discontinuation in 34/119 (28.6%). Conclusions: oxaliplatin retreatment produced further RR in around one-fifth of patients and DCR 57.8%. Efficacy decreased in more pre-treated patients and around one-third of patients discontinued treatment due to adverse events. Translational studies improving patient selection are warranted.
continuum-of-care; oxaliplatin; rechallenge; reintroduction
Settore MED/06 - Oncologia Medica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/938993
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