Background Henoch-Schönlein purpura (HSP) is an IgA-mediated small vessel vasculitis, typical of childhood. It’s a self-limiting disease and it affects different systems. HSP is characterized by dermatological, abdominal, joint and renal clinical manifestations. This condition usually occurs upon infections, mainly upper respiratory tract ones, medications, vaccinations and malignancies. Case presentation We describe the case of a 11 year-old girl who developed a urticarial rash 12 days after the first dose of Pfizer-BioNTech BNT16B2b2 mRNA vaccine and a clear picture of Henoch Schönlein purpura 5 days after administration of the second dose of the same vaccine. Conclusion To our knowledge, this is the first description of a pediatric patient with Henoch-Schönlein purpura occurring in association with vaccination against COVID-19.

Henoch-Schönlein purpura following COVID-19 vaccine in a child : a case report / F. Casini, V.C. Magenes, M. De Sanctis, M. Gattinara, M. Pandolfi, S. Cambiaghi, G.V. Zuccotti, V. Fabiano. - In: THE ITALIAN JOURNAL OF PEDIATRICS. - ISSN 1720-8424. - 48:1(2022 Sep), pp. 158.1-158.7. [10.1186/s13052-022-01351-1]

Henoch-Schönlein purpura following COVID-19 vaccine in a child : a case report

F. Casini
Primo
;
V.C. Magenes
Secondo
;
M. Pandolfi;G.V. Zuccotti
Penultimo
;
V. Fabiano
Ultimo
2022

Abstract

Background Henoch-Schönlein purpura (HSP) is an IgA-mediated small vessel vasculitis, typical of childhood. It’s a self-limiting disease and it affects different systems. HSP is characterized by dermatological, abdominal, joint and renal clinical manifestations. This condition usually occurs upon infections, mainly upper respiratory tract ones, medications, vaccinations and malignancies. Case presentation We describe the case of a 11 year-old girl who developed a urticarial rash 12 days after the first dose of Pfizer-BioNTech BNT16B2b2 mRNA vaccine and a clear picture of Henoch Schönlein purpura 5 days after administration of the second dose of the same vaccine. Conclusion To our knowledge, this is the first description of a pediatric patient with Henoch-Schönlein purpura occurring in association with vaccination against COVID-19.
Henoch-Schönlein purpura (HSP); case report; COVID-19 vaccine; Pfizer-BioNTech BNT16B2b2 mRNA vaccine; IgA-mediated vasculitis
Settore MED/38 - Pediatria Generale e Specialistica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/937072
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