More than 50% of all patients with colorectal cancer (CRC) develop liver metastases (CLM), a clinical condition characterized by poor prognosis and lack of reliable prognostic markers. Vδ1 cells are a subset of tissue-resident gamma delta (γδ) T lymphocytes endowed with a broad array of antitumor functions and showing a natural high tropism for the liver. However, little is known about their impact in the clinical outcomes of CLM.

Intrahepatic CD69+Vδ1 T cells re-circulate in the blood of patients with metastatic colorectal cancer and limit tumor progression / E. Bruni, M.M. Cimino, M. Donadon, R. Carriero, S. Terzoli, R. Piazza, S. Ravens, I. Prinz, V. Cazzetta, P. Marzano, P. Kunderfranco, C. Peano, C. Soldani, B. Franceschini, F.S. Colombo, C. Garlanda, A. Mantovani, G. Torzilli, J. Mikulak, D. Mavilio. - In: JOURNAL FOR IMMUNOTHERAPY OF CANCER. - ISSN 2051-1426. - 10:7(2022), pp. e004579.1-e004579.30. [10.1136/jitc-2022-004579]

Intrahepatic CD69+Vδ1 T cells re-circulate in the blood of patients with metastatic colorectal cancer and limit tumor progression

M.M. Cimino;M. Donadon;V. Cazzetta;P. Marzano;F.S. Colombo;A. Mantovani;G. Torzilli;J. Mikulak
Penultimo
;
D. Mavilio
Ultimo
2022

Abstract

More than 50% of all patients with colorectal cancer (CRC) develop liver metastases (CLM), a clinical condition characterized by poor prognosis and lack of reliable prognostic markers. Vδ1 cells are a subset of tissue-resident gamma delta (γδ) T lymphocytes endowed with a broad array of antitumor functions and showing a natural high tropism for the liver. However, little is known about their impact in the clinical outcomes of CLM.
T-lymphocytes; immunity, cellular; immunologic surveillance; liver neoplasms; lymphocytes, tumor-infiltrating; Humans; Immunotherapy; Lymphocytes, Tumor-Infiltrating; Receptors, Antigen, T-Cell, gamma-delta; Tumor Microenvironment; Colorectal Neoplasms; T-Lymphocyte Subsets
Settore MED/46 - Scienze Tecniche di Medicina di Laboratorio
Settore MED/04 - Patologia Generale
Settore MED/06 - Oncologia Medica
Settore MED/12 - Gastroenterologia
2022
21-lug-2022
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/935053
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