SIRT5 is a member of the Sirtuin family, a class of deacetylating enzymes consisting of seven isoforms, involved in the regulation of several processes, including gene expression, metabolism, stress response, and aging. Considering that the anomalous activity of SIRT5 is linked to many pathological conditions, we present herein an overview of the most interesting modulators, with the aim of contributing to further development in this field.

Insights on the Modulation of SIRT5 Activity: A Challenging Balance / M. Mori, G. Cazzaniga, F. Meneghetti, S. Villa, A. Gelain. - In: MOLECULES. - ISSN 1420-3049. - 27:14(2022 Jul 12), pp. 4449-1. [10.3390/molecules27144449]

Insights on the Modulation of SIRT5 Activity: A Challenging Balance

M. Mori
Primo
;
G. Cazzaniga
Secondo
;
F. Meneghetti;S. Villa
Penultimo
;
A. Gelain
Ultimo
2022-07-12

Abstract

SIRT5 is a member of the Sirtuin family, a class of deacetylating enzymes consisting of seven isoforms, involved in the regulation of several processes, including gene expression, metabolism, stress response, and aging. Considering that the anomalous activity of SIRT5 is linked to many pathological conditions, we present herein an overview of the most interesting modulators, with the aim of contributing to further development in this field.
Sirtuin 5; HDACs; activators; inhibitors; natural compounds; small molecules;
Settore CHIM/08 - Chimica Farmaceutica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/934006
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