The autonomic nervous system (ANS) and the immune system are deeply interrelated. The ANS regulates both innate and adaptive immunity through the sympathetic and parasympathetic branches, and an imbalance in this system can determine an altered inflammatory response as typically observed in chronic conditions such as systemic autoimmune diseases. Rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis all show a dysfunction of the ANS that is mutually related to the increase in inflammation and cardiovascular risk. Moreover, an interaction between ANS and the gut microbiota has direct effects on inflammation homeostasis. Recently vagal stimulation techniques have emerged as an unprecedented possibility to reduce ANS dysfunction, especially in chronic diseases characterized by pain and a decreased quality of life as well as in chronic inflammation.

The interplay between autonomic nervous system and inflammation across systemic autoimmune diseases / C. Bellocchi, A. Carandina, B.L. Montinaro, E.L.A. Targetti, L. Furlan, G. Dias Rodrigues, E. Tobaldini, N. Montano. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 23:5(2022 Feb 23), pp. 2449.1-2449.15. [10.3390/ijms23052449]

The interplay between autonomic nervous system and inflammation across systemic autoimmune diseases

C. Bellocchi
Primo
;
A. Carandina;B.L. Montinaro;E.L.A. Targetti;L. Furlan;G. Dias Rodrigues;E. Tobaldini
Penultimo
;
N. Montano
Ultimo
2022-02-23

Abstract

The autonomic nervous system (ANS) and the immune system are deeply interrelated. The ANS regulates both innate and adaptive immunity through the sympathetic and parasympathetic branches, and an imbalance in this system can determine an altered inflammatory response as typically observed in chronic conditions such as systemic autoimmune diseases. Rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis all show a dysfunction of the ANS that is mutually related to the increase in inflammation and cardiovascular risk. Moreover, an interaction between ANS and the gut microbiota has direct effects on inflammation homeostasis. Recently vagal stimulation techniques have emerged as an unprecedented possibility to reduce ANS dysfunction, especially in chronic diseases characterized by pain and a decreased quality of life as well as in chronic inflammation.
autonomic nervous system; sympathetic system; parasympathetic system; inflammatory reflex; innate immunity; adaptive immunity; systemic autoimmune diseases; inflammation; gut microbiota
Settore MED/09 - Medicina Interna
Settore MED/16 - Reumatologia
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/932971
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