HDL (High-density lipoprotein) and its major protein component, apoA-I (apolipoprotein A-I), play a unique role in cholesterol homeostasis and immunity. ApoA-I deficiency in hyperlipidemic, atheroprone mice was shown to drive cholesterol accumulation and inflammatory cell activation/proliferation. The present study was aimed at investigating the impact of apoA-I deficiency on lipid deposition and local/systemic inflammation in normolipidemic conditions.

Lack of ApoA-I in ApoEKO Mice Causes Skin Xanthomas, Worsening of Inflammation, and Increased Coronary Atherosclerosis in the Absence of Hyperlipidemia / M. Busnelli, S. Manzini, A. Colombo, E. Franchi, F. Bonacina, M. Chiara, F. Arnaboldi, E.B. Donetti, F. Ambrogi, R. Oleari, A. Lettieri, D.S. Horner, E. Scanziani, G.D. Norata, G.M.C. Chiesa. - In: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. - ISSN 1079-5642. - (2022). [Epub ahead of print] [10.1161/ATVBAHA.122.317790]

Lack of ApoA-I in ApoEKO Mice Causes Skin Xanthomas, Worsening of Inflammation, and Increased Coronary Atherosclerosis in the Absence of Hyperlipidemia

M. Busnelli
Primo
;
S. Manzini
Secondo
;
A. Colombo;E. Franchi;F. Bonacina;M. Chiara;F. Arnaboldi;E.B. Donetti;F. Ambrogi;R. Oleari;A. Lettieri;D.S. Horner;E. Scanziani;G.D. Norata
Penultimo
;
G.M.C. Chiesa
Ultimo
2022

Abstract

HDL (High-density lipoprotein) and its major protein component, apoA-I (apolipoprotein A-I), play a unique role in cholesterol homeostasis and immunity. ApoA-I deficiency in hyperlipidemic, atheroprone mice was shown to drive cholesterol accumulation and inflammatory cell activation/proliferation. The present study was aimed at investigating the impact of apoA-I deficiency on lipid deposition and local/systemic inflammation in normolipidemic conditions.
atherosclerosis; hyperlipidemias; inflammation; lymph nodes; xanthoma
Settore BIO/16 - Anatomia Umana
JPI_MIUR19GCHIE_01 - A sound microbiota in a sound body through apolipoprotein A-I and HDL: from mouse models to humans (OCTOPUS) - CHIESA, GIULIA MARIA CAROLA - JPI_MIUR - Joint Programming Initiatives_MIUR - 2019
19-mag-2022
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/929950
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