In vitro experiments on actin polymerization in the presence of doxorubicin show that the rate of salt-induced actin assembly is negatively affected by the drug. The decreased amount of actin monomers keeping their ability to self-interact to give F actin (microfilaments) probably explains the reduction of assembly value. Drug action is dose-dependent and various discrepancies are explained by the limitations of the techniques used.
Doxorubicin affects actin assembly in vitro / R. Colombo, A. Necco, G. Vailati, B. Saracco, A. Milzani, G. Scari'. - In: CELL BIOLOGY INTERNATIONAL REPORTS. - ISSN 0309-1651. - 8:2(1984), pp. 127-135. [10.1016/0309-1651(84)90079-1]
Doxorubicin affects actin assembly in vitro
R. Colombo;G. Vailati;A. Milzani;G. Scari'
Investigation
1984
Abstract
In vitro experiments on actin polymerization in the presence of doxorubicin show that the rate of salt-induced actin assembly is negatively affected by the drug. The decreased amount of actin monomers keeping their ability to self-interact to give F actin (microfilaments) probably explains the reduction of assembly value. Drug action is dose-dependent and various discrepancies are explained by the limitations of the techniques used.
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