Tuberculosis and COVID-19 co-infection: description of the global cohort

Migliori, G.B.; Casco, N.; Jorge, A.L.; Palmero, D.J.; Alffenaar, J.-.; Denholm, J.; Fox, G.J.; Ezz, W.; Cho, J.-.; Skrahina, A.; Solodovnikova, V.; Bachez, P.; Piubello, A.; Arbex, M.A.; Alves, T.; Rabahi, M.F.; Pereira, G.R.; Sales, R.; Silva, D.R.; Saffie, M.M.; Miranda, R.C.; Cancino, V.; Carbonell, M.; Cisterna, C.; Concha, C.; Cruz, A.; Salinas, N.E.; Revillot, M.E.; Valdes, J.F.; Fernandez, I.; Flores, X.; Tapia, P.G.; Garavagno, A.; Vera, C.G.; Bahamondes, M.H.; Merino, L.M.; Munoz, E.; Munoz, C.; Navarro, I.; Subiabre, J.N.; Ortega, C.; Palma, S.; Pradenas, A.M.; Pereira, G.; Castillo, P.P.; Pinto, M.; Pizarro, R.; Bidegain, F.R.; Rodriguez, P.; Sanchez, C.; Salinas, A.S.; Soto, A.; Taiba, C.; Venegas, M.; Riquelme, M.S.V.; Vilca, E.; Villalon, C.; Yucra, E.; Li, Y.; Cruz, A.; Guelvez, B.; Plaza, R.V.; Hoyos, K.Y.T.; Andrejak, C.; Blanc, F.-.; Dourmane, S.; Froissart, A.; Izadifar, A.; Riviere, F.; Schlemmer, F.; Manika, K.; Diallo, B.D.; Hassane-Harouna, S.; Artiles, N.; Mejia, L.A.; Gupta, N.; Ish, P.; Mishra, G.; Sharma, S.; Singla, R.; Udwadia, Z.F.; Alladio, F.; Angeli, F.; Calcagno, A.; Centis, R.; Codecasa, L.R.; D'Ambrosio, L.; De Lauretis, A.; Esposito, S.; Formenti, B.; Gaviraghi, A.; Giacomet, V.; Goletti, D.; Gualano, G.; Matteelli, A.; Migliori, G.B.; Motta, I.; Palmieri, F.; Pontali, E.; Prestileo, T.; Riccardi, N.; Saderi, L.; Saporiti, M.; Sotgiu, G.; Stochino, C.; Tadolini, M.; Torre, A.; Villa, S.; Visca, D.; Danila, E.; Diktanas, S.; Ridaura, R.L.; Lopez, F.L.L.; Torrico, M.M.; Rendon, A.; Akkerman, O.W.; Souleymane, M.B.; Al-Abri, S.; Alyaquobi, F.; Althohli, K.; Aizpurua, E.; Gonzales, R.; Jurado, J.; Loban, A.; Aguirre, S.; Teixeira, R.C.; De Egea, V.; Irala, S.; Medina, A.; Sequera, G.; Sosa, N.; Vazquez, F.; Llanos-Tejada, F.K.; Manga, S.; Villanueva-Villegas, R.; Araujo, D.; Duarte, R.; Marques, T.S.; Grecu, V.I.; Socaci, A.; Barkanova, O.; Bogorodskaya, M.; Borisov, S.; Mariandyshev, A.; Kaluzhenina, A.; Vukicevic, T.A.; Stosic, M.; Beh, D.; Ng, D.; Ong, C.W.M.; Solovic, I.; Dheda, K.; Gina, P.; Caminero, J.A.; Cardoso-Landivar, J.; De Souza Galvao, M.L.; Dominguez-Castellano, A.; Garcia-Garcia, J.-.; Pinargote, I.M.; Fernandez, S.Q.; Sanchez-Montalva, A.; Huguet, E.T.; Murguiondo, M.Z.; Bart, P.-.; Mazza-Stalder, J.; Bakko, F.; Barnacle, J.; Brown, A.; Chandran, S.; Killington, K.; Man, K.; Papineni, P.; Tiberi, S.; Utjesanovic, N.; Zenner, D.; Hearn, J.L.; Heysell, S.; Young, L.

doi:10.1183/13993003.02538-2021

Background: Information on tuberculosis (TB) and coronavirus disease 2019 (COVID-19) is still limited. The aim of this study was to describe the features of the TB/COVID-19 co-infected individuals from a prospective, anonymised, multicountry register-based cohort with special focus on the determinants of mortality and other outcomes. Methods: We enrolled all patients of any age with either active TB or previous TB and COVID-19. 172 centres from 34 countries provided individual data on 767 TB-COVID-19 co-infected patients, (>50% population-based). Results: Of 767 patients, 553 (74.0%) out of 747 had TB before COVID-19 (including 234 out of 747 with previous TB), 71 (9.5%) out of 747 had COVID-19 first and 123 (16.5%) out of 747 had both diseases diagnosed within the same week (n=35 (4.6%) on the same day). 85 (11.08%) out of 767 patients died (41 (14.2%) out of 289 in Europe and 44 (9.2%) out of 478 outside Europe; p=0.03): 42 (49.4%) from COVID-19, 31 (36.5%) from COVID-19 and TB, one (1.2%) from TB and 11 from other causes. In the univariate analysis on mortality the following variables reached statistical significance: age, male gender, having more than one comorbidity, diabetes mellitus, cardiovascular disease, chronic respiratory disease, chronic renal disease, presence of key symptoms, invasive ventilation and hospitalisation due to COVID-19. The final multivariable logistic regression model included age, male gender and invasive ventilation as independent contributors to mortality. Conclusion: The data suggest that TB and COVID-19 are a "cursed duet" and need immediate attention. TB should be considered a risk factor for severe COVID disease and patients with TB should be prioritised for COVID-19 preventative efforts, including vaccination. (The TB/COVID-19 Global Study Group)

Tuberculosis and COVID-19 co-infection: description of the global cohort / G.B. Migliori, N. Casco, A.L. Jorge, D.J. Palmero, J.-. Alffenaar, J. Denholm, G.J. Fox, W. Ezz, J.-. Cho, A. Skrahina, V. Solodovnikova, P. Bachez, A. Piubello, M.A. Arbex, T. Alves, M.F. Rabahi, G.R. Pereira, R. Sales, D.R. Silva, M.M. Saffie, R.C. Miranda, V. Cancino, M. Carbonell, C. Cisterna, C. Concha, A. Cruz, N.E. Salinas, M.E. Revillot, J.F. Valdes, I. Fernandez, X. Flores, P.G. Tapia, A. Garavagno, C.G. Vera, M.H. Bahamondes, L.M. Merino, E. Munoz, C. Munoz, I. Navarro, J.N. Subiabre, C. Ortega, S. Palma, A.M. Pradenas, G. Pereira, P.P. Castillo, M. Pinto, R. Pizarro, F.R. Bidegain, P. Rodriguez, C. Sanchez, A.S. Salinas, A. Soto, C. Taiba, M. Venegas, M.S.V. Riquelme, E. Vilca, C. Villalon, E. Yucra, Y. Li, A. Cruz, B. Guelvez, R.V. Plaza, K.Y.T. Hoyos, C. Andrejak, F.-. Blanc, S. Dourmane, A. Froissart, A. Izadifar, F. Riviere, F. Schlemmer, K. Manika, B.D. Diallo, S. Hassane-Harouna, N. Artiles, L.A. Mejia, N. Gupta, P. Ish, G. Mishra, S. Sharma, R. Singla, Z.F. Udwadia, F. Alladio, F. Angeli, A. Calcagno, R. Centis, L.R. Codecasa, L. D'Ambrosio, A. De Lauretis, S. Esposito, B. Formenti, A. Gaviraghi, V. Giacomet, D. Goletti, G. Gualano, A. Matteelli, G.B. Migliori, I. Motta, F. Palmieri, E. Pontali, T. Prestileo, N. Riccardi, L. Saderi, M. Saporiti, G. Sotgiu, C. Stochino, M. Tadolini, A. Torre, S. Villa, D. Visca, E. Danila, S. Diktanas, R.L. Ridaura, F.L.L. Lopez, M.M. Torrico, A. Rendon, O.W. Akkerman, M.B. Souleymane, S. Al-Abri, F. Alyaquobi, K. Althohli, E. Aizpurua, R. Gonzales, J. Jurado, A. Loban, S. Aguirre, R.C. Teixeira, V. De Egea, S. Irala, A. Medina, G. Sequera, N. Sosa, F. Vazquez, F.K. Llanos-Tejada, S. Manga, R. Villanueva-Villegas, D. Araujo, R. Duarte, T.S. Marques, V.I. Grecu, A. Socaci, O. Barkanova, M. Bogorodskaya, S. Borisov, A. Mariandyshev, A. Kaluzhenina, T.A. Vukicevic, M. Stosic, D. Beh, D. Ng, C.W.M. Ong, I. Solovic, K. Dheda, P. Gina, J.A. Caminero, J. Cardoso-Landivar, M.L. De Souza Galvao, A. Dominguez-Castellano, J.-. Garcia-Garcia, I.M. Pinargote, S.Q. Fernandez, A. Sanchez-Montalva, E.T. Huguet, M.Z. Murguiondo, P.-. Bart, J. Mazza-Stalder, F. Bakko, J. Barnacle, A. Brown, S. Chandran, K. Killington, K. Man, P. Papineni, S. Tiberi, N. Utjesanovic, D. Zenner, J.L. Hearn, S. Heysell, L. Young. - In: EUROPEAN RESPIRATORY JOURNAL. - ISSN 0903-1936. - 59:3(2022 Mar 01), pp. 2102538.1-2102538.15. [10.1183/13993003.02538-2021]

Tuberculosis and COVID-19 co-infection: description of the global cohort

Migliori G. B.;Casco N.;Jorge A. L.;Palmero D. J.;Alffenaar J. -W.;Denholm J.;Fox G. J.;Ezz W.;Cho J. -G.;Skrahina A.;Solodovnikova V.;Bachez P.;Piubello A.;Arbex M. A.;Alves T.;Rabahi M. F.;Pereira G. R.;Sales R.;Silva D. R.;Saffie M. M.;Miranda R. C.;Cancino V.;Carbonell M.;Cisterna C.;Concha C.;Cruz A.;Salinas N. E.;Revillot M. E.;Valdes J. F.;Fernandez I.;Flores X.;Tapia P. G.;Garavagno A.;Vera C. G.;Bahamondes M. H.;Merino L. M.;Munoz E.;Munoz C.;Navarro I.;Subiabre J. N.;Ortega C.;Palma S.;Pradenas A. M.;Pereira G.;Castillo P. P.;Pinto M.;Pizarro R.;Bidegain F. R.;Rodriguez P.;Sanchez C.;Salinas A. S.;Soto A.;Taiba C.;Venegas M.;Riquelme M. S. V.;Vilca E.;Villalon C.;Yucra E.;Li Y.;Cruz A.;Guelvez B.;Plaza R. V.;Hoyos K. Y. T.;Andrejak C.;Blanc F. -X.;Dourmane S.;Froissart A.;Izadifar A.;Riviere F.;Schlemmer F.;Manika K.;Diallo B. D.;Hassane-Harouna S.;Artiles N.;Mejia L. A.;Gupta N.;Ish P.;Mishra G.;Sharma S.;Singla R.;Udwadia Z. F.;Alladio F.;Angeli F.;Calcagno A.;Centis R.;Codecasa L. R.;D'Ambrosio L.;De Lauretis A.;Esposito S.;Formenti B.;Gaviraghi A.;V. Giacomet^{Membro del Collaboration Group};Goletti D.;Gualano G.;Matteelli A.;Migliori G. B.;Motta I.^{Membro del Collaboration Group};Palmieri F.;Pontali E.;Prestileo T.;Riccardi N.;Saderi L.;Saporiti M.;Sotgiu G.;Stochino C.;Tadolini M.;Torre A.;S. Villa^{Membro del Collaboration Group};Visca D.;Danila E.;Diktanas S.;Ridaura R. L.;Lopez F. L. L.;Torrico M. M.;Rendon A.;Akkerman O. W.;Souleymane M. B.;Al-Abri S.;Alyaquobi F.;Althohli K.;Aizpurua E.;Gonzales R.;Jurado J.;Loban A.;Aguirre S.;Teixeira R. C.;De Egea V.;Irala S.;Medina A.;Sequera G.;Sosa N.;Vazquez F.;Llanos-Tejada F. K.;Manga S.;Villanueva-Villegas R.;Araujo D.;Duarte R.;Marques T. S.;Grecu V. I.;Socaci A.;Barkanova O.;Bogorodskaya M.;Borisov S.;Mariandyshev A.;Kaluzhenina A.;Vukicevic T. A.;Stosic M.;Beh D.;Ng D.;Ong C. W. M.;Solovic I.;Dheda K.;Gina P.;Caminero J. A.;Cardoso-Landivar J.;De Souza Galvao M. L.;Dominguez-Castellano A.;Garcia-Garcia J. -M.;Pinargote I. M.;Fernandez S. Q.;Sanchez-Montalva A.;Huguet E. T.;Murguiondo M. Z.;Bart P. -A.;Mazza-Stalder J.;Bakko F.;Barnacle J.;Brown A.;Chandran S.;Killington K.;Man K.;Papineni P.;Tiberi S.;Utjesanovic N.;Zenner D.;Hearn J. L.;Heysell S.;Young L.

2022

Abstract

Background: Information on tuberculosis (TB) and coronavirus disease 2019 (COVID-19) is still limited. The aim of this study was to describe the features of the TB/COVID-19 co-infected individuals from a prospective, anonymised, multicountry register-based cohort with special focus on the determinants of mortality and other outcomes. Methods: We enrolled all patients of any age with either active TB or previous TB and COVID-19. 172 centres from 34 countries provided individual data on 767 TB-COVID-19 co-infected patients, (>50% population-based). Results: Of 767 patients, 553 (74.0%) out of 747 had TB before COVID-19 (including 234 out of 747 with previous TB), 71 (9.5%) out of 747 had COVID-19 first and 123 (16.5%) out of 747 had both diseases diagnosed within the same week (n=35 (4.6%) on the same day). 85 (11.08%) out of 767 patients died (41 (14.2%) out of 289 in Europe and 44 (9.2%) out of 478 outside Europe; p=0.03): 42 (49.4%) from COVID-19, 31 (36.5%) from COVID-19 and TB, one (1.2%) from TB and 11 from other causes. In the univariate analysis on mortality the following variables reached statistical significance: age, male gender, having more than one comorbidity, diabetes mellitus, cardiovascular disease, chronic respiratory disease, chronic renal disease, presence of key symptoms, invasive ventilation and hospitalisation due to COVID-19. The final multivariable logistic regression model included age, male gender and invasive ventilation as independent contributors to mortality. Conclusion: The data suggest that TB and COVID-19 are a "cursed duet" and need immediate attention. TB should be considered a risk factor for severe COVID disease and patients with TB should be prioritised for COVID-19 preventative efforts, including vaccination. (The TB/COVID-19 Global Study Group)

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	Lingua dell'articolo
	
			English
		
	Parole chiave
	
			Cohort Studies; Humans; Male; Prospective Studies; COVID-19; Coinfection; Tuberculosis:
		
	Settori scientifico-disciplinari dell'articolo
	
			Settore MED/42 - Igiene Generale e Applicata
		
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			Articolo
		
	Revisione (peer review)
	
			Esperti anonimi
		
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			Pubblicazione scientifica
		
	Sustainable development goals
	
			Goal 3: Good health and well-being
		
	Data di pubblicazione
	
			1-mar-2022
		
	Rivista in ANCE
	
			EUROPEAN RESPIRATORY JOURNAL
		
	Editore
	
			European Respiratory Society
		
	Volume o annata
	
			59
		
	Fascicolo
	
			3
		
	Numero dell'articolo
	
			2102538
		
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			1
		
	Pagina finale
	
			15
		
	Numero di pagine
	
			15
		
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	DOI
	
			https://dx.doi.org/10.1183/13993003.02538-2021
		
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			2-s2.0-85126711481
		
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	Adesione alla policy Open Access di Ateneo
	
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			info:eu-repo/semantics/article
		
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			Tuberculosis and COVID-19 co-infection: description of the global cohort / G.B. Migliori, N. Casco, A.L. Jorge, D.J. Palmero, J.-. Alffenaar, J. Denholm, G.J. Fox, W. Ezz, J.-. Cho, A. Skrahina, V. Solodovnikova, P. Bachez, A. Piubello, M.A. Arbex, T. Alves, M.F. Rabahi, G.R. Pereira, R. Sales, D.R. Silva, M.M. Saffie, R.C. Miranda, V. Cancino, M. Carbonell, C. Cisterna, C. Concha, A. Cruz, N.E. Salinas, M.E. Revillot, J.F. Valdes, I. Fernandez, X. Flores, P.G. Tapia, A. Garavagno, C.G. Vera, M.H. Bahamondes, L.M. Merino, E. Munoz, C. Munoz, I. Navarro, J.N. Subiabre, C. Ortega, S. Palma, A.M. Pradenas, G. Pereira, P.P. Castillo, M. Pinto, R. Pizarro, F.R. Bidegain, P. Rodriguez, C. Sanchez, A.S. Salinas, A. Soto, C. Taiba, M. Venegas, M.S.V. Riquelme, E. Vilca, C. Villalon, E. Yucra, Y. Li, A. Cruz, B. Guelvez, R.V. Plaza, K.Y.T. Hoyos, C. Andrejak, F.-. Blanc, S. Dourmane, A. Froissart, A. Izadifar, F. Riviere, F. Schlemmer, K. Manika, B.D. Diallo, S. Hassane-Harouna, N. Artiles, L.A. Mejia, N. Gupta, P. Ish, G. Mishra, S. Sharma, R. Singla, Z.F. Udwadia, F. Alladio, F. Angeli, A. Calcagno, R. Centis, L.R. Codecasa, L. D'Ambrosio, A. De Lauretis, S. Esposito, B. Formenti, A. Gaviraghi, V. Giacomet, D. Goletti, G. Gualano, A. Matteelli, G.B. Migliori, I. Motta, F. Palmieri, E. Pontali, T. Prestileo, N. Riccardi, L. Saderi, M. Saporiti, G. Sotgiu, C. Stochino, M. Tadolini, A. Torre, S. Villa, D. Visca, E. Danila, S. Diktanas, R.L. Ridaura, F.L.L. Lopez, M.M. Torrico, A. Rendon, O.W. Akkerman, M.B. Souleymane, S. Al-Abri, F. Alyaquobi, K. Althohli, E. Aizpurua, R. Gonzales, J. Jurado, A. Loban, S. Aguirre, R.C. Teixeira, V. De Egea, S. Irala, A. Medina, G. Sequera, N. Sosa, F. Vazquez, F.K. Llanos-Tejada, S. Manga, R. Villanueva-Villegas, D. Araujo, R. Duarte, T.S. Marques, V.I. Grecu, A. Socaci, O. Barkanova, M. Bogorodskaya, S. Borisov, A. Mariandyshev, A. Kaluzhenina, T.A. Vukicevic, M. Stosic, D. Beh, D. Ng, C.W.M. Ong, I. Solovic, K. Dheda, P. Gina, J.A. Caminero, J. Cardoso-Landivar, M.L. De Souza Galvao, A. Dominguez-Castellano, J.-. Garcia-Garcia, I.M. Pinargote, S.Q. Fernandez, A. Sanchez-Montalva, E.T. Huguet, M.Z. Murguiondo, P.-. Bart, J. Mazza-Stalder, F. Bakko, J. Barnacle, A. Brown, S. Chandran, K. Killington, K. Man, P. Papineni, S. Tiberi, N. Utjesanovic, D. Zenner, J.L. Hearn, S. Heysell, L. Young. - In: EUROPEAN RESPIRATORY JOURNAL. - ISSN 0903-1936. - 59:3(2022 Mar 01), pp. 2102538.1-2102538.15. [10.1183/13993003.02538-2021]
		
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			G.B. Migliori, N. Casco, A.L. Jorge, D.J. Palmero, J.-. Alffenaar, J. Denholm, G.J. Fox, W. Ezz, J.-. Cho, A. Skrahina, V. Solodovnikova, P. Bachez, A. Piubello, M.A. Arbex, T. Alves, M.F. Rabahi, G.R. Pereira, R. Sales, D.R. Silva, M.M. Saffie, R.C. Miranda, V. Cancino, M. Carbonell, C. Cisterna, C. Concha, A. Cruz, N.E. Salinas, M.E. Revillot, J.F. Valdes, I. Fernandez, X. Flores, P.G. Tapia, A. Garavagno, C.G. Vera, M.H. Bahamondes, L.M. Merino, E. Munoz, C. Munoz, I. Navarro, J.N. Subiabre, C. Ortega, S. Palma, A.M. Pradenas, G. Pereira, P.P. Castillo, M. Pinto, R. Pizarro, F.R. Bidegain, P. Rodriguez, C. Sanchez, A.S. Salinas, A. Soto, C. Taiba, M. Venegas, M.S.V. Riquelme, E. Vilca, C. Villalon, E. Yucra, Y. Li, A. Cruz, B. Guelvez, R.V. Plaza, K.Y.T. Hoyos, C. Andrejak, F.-. Blanc, S. Dourmane, A. Froissart, A. Izadifar, F. Riviere, F. Schlemmer, K. Manika, B.D. Diallo, S. Hassane-Harouna, N. Artiles, L.A. Mejia, N. Gupta, P. Ish, G. Mishra, S. Sharma, R. Singla, Z.F. Udwadia, F. Alladio, F. Angeli, A. Calcagno, R. Centis, L.R. Codecasa, L. D'Ambrosio, A. De Lauretis, S. Esposito, B. Formenti, A. Gaviraghi, V. Giacomet, D. Goletti, G. Gualano, A. Matteelli, G.B. Migliori, I. Motta, F. Palmieri, E. Pontali, T. Prestileo, N. Riccardi, L. Saderi, M. Saporiti, G. Sotgiu, C. Stochino, M. Tadolini, A. Torre, S. Villa, D. Visca, E. Danila, S. Diktanas, R.L. Ridaura, F.L.L. Lopez, M.M. Torrico, A. Rendon, O.W. Akkerman, M.B. Souleymane, S. Al-Abri, F. Alyaquobi, K. Althohli, E. Aizpurua, R. Gonzales, J. Jurado, A. Loban, S. Aguirre, R.C. Teixeira, V. De Egea, S. Irala, A. Medina, G. Sequera, N. Sosa, F. Vazquez, F.K. Llanos-Tejada, S. Manga, R. Villanueva-Villegas, D. Araujo, R. Duarte, T.S. Marques, V.I. Grecu, A. Socaci, O. Barkanova, M. Bogorodskaya, S. Borisov, A. Mariandyshev, A. Kaluzhenina, T.A. Vukicevic, M. Stosic, D. Beh, D. Ng, C.W.M. Ong, I. Solovic, K. Dheda, P. Gina, J.A. Caminero, J. Cardoso-Landivar, M.L. De Souza Galvao, A. Dominguez-Castellano, J.-. Garcia-Garcia, I.M. Pinargote, S.Q. Fernandez, A. Sanchez-Montalva, E.T. Huguet, M.Z. Murguiondo, P.-. Bart, J. Mazza-Stalder, F. Bakko, J. Barnacle, A. Brown, S. Chandran, K. Killington, K. Man, P. Papineni, S. Tiberi, N. Utjesanovic, D. Zenner, J.L. Hearn, S. Heysell, L. Young
		
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