Iron is a central role in a variety of essential cellular functions as oxygen transport and exchange, being the metal component of many intracellular enzymes. Its ability to react with oxygen also makes it a toxic compound, able to generate reactive oxygen species (ROS) that can damage DNA, phospholipids and proteins. It is therefore of utmost importance, for both the cells and the organisms, to maintain iron homeostasis, ensuring iron supply and preventing accumulation of iron excess.
Iron homeostasis in beta-cells / M. Castagna, A. Marku, A. Galli, P. Marciani, N. Dule, C. Perego. - (2021).
Iron homeostasis in beta-cells
M. Castagna
;A. Marku;A. Galli;P. Marciani;N. Dule;C. Perego
2021
Abstract
Iron is a central role in a variety of essential cellular functions as oxygen transport and exchange, being the metal component of many intracellular enzymes. Its ability to react with oxygen also makes it a toxic compound, able to generate reactive oxygen species (ROS) that can damage DNA, phospholipids and proteins. It is therefore of utmost importance, for both the cells and the organisms, to maintain iron homeostasis, ensuring iron supply and preventing accumulation of iron excess.
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