Background: Mortality rate from COVID-19 in Italy is among the world’s highest. We aimed to ascertain whether there was any reduction of in-hospital mortality in patients hospitalised for COVID-19 in the second-wave period (October 2020–January 2021) compared to the first one (February–May 2020); further, we verified whether there were clusters of hospitalised patients who particularly benefitted from reduced mortality rate. Methods: Data collected related to in-patients’ demographics, clinical, laboratory, therapies and outcome. Primary end-point was time to in-hospital death. Factors associated were evaluated by uni-and multivariable analyses. A flow diagram was created to determine the rate of in-hospital death according to individual and disease characteristics. Results: A total of 1561 patients were included. The 14-day cumulative incidence of in-hospital death by competing risk regression was of 24.8% (95% CI: 21.3–28.5) and 15.9% (95% CI: 13.7–18.2) in the first and second wave. We observed that the highest relative reduction of death from first to second wave (more than 47%) occurred mainly in the clusters of patients younger than 70 years. Conclusions: Progress in care and supporting therapies did affect population over 70 years to a lesser extent. Preventive and vaccination campaigns should focus on individuals whose risk of death from COVID-19 remains high.

Declining mortality rate of hospitalised patients in the second wave of the COVID-19 epidemics in Italy : Risk factors and the age-specific patterns / A. D'Arminio Monforte, A. Tavelli, F. Bai, D. Tomasoni, C. Falcinella, R. Castoldi, D. Barbanotti, G. Mule, M. Allegrini, E. Suardi, D. Tesoro, G. Tagliaferri, D. Mondatore, M. Augello, A. Cona, T. Beringheli, N. Gemignani, M. Sala, B. Varisco, F. Mola, S. Pettenuzzo, L. Biasioli, A. Copes, L. Gazzola, O. Vigano, C. Tincati, A. De Bona, T. Bini, G. Marchetti. - In: LIFE. - ISSN 2075-1729. - 11:9(2021 Sep), pp. 979.1-979.9. [10.3390/life11090979]

Declining mortality rate of hospitalised patients in the second wave of the COVID-19 epidemics in Italy : Risk factors and the age-specific patterns

A. D'Arminio Monforte
Primo
;
F. Bai;C. Falcinella;D. Barbanotti;M. Allegrini;E. Suardi;D. Tesoro;G. Tagliaferri;D. Mondatore;M. Augello;A. Cona;T. Beringheli;N. Gemignani;B. Varisco;F. Mola;S. Pettenuzzo;L. Biasioli;A. Copes;L. Gazzola;C. Tincati;G. Marchetti
Ultimo
2021-09

Abstract

Background: Mortality rate from COVID-19 in Italy is among the world’s highest. We aimed to ascertain whether there was any reduction of in-hospital mortality in patients hospitalised for COVID-19 in the second-wave period (October 2020–January 2021) compared to the first one (February–May 2020); further, we verified whether there were clusters of hospitalised patients who particularly benefitted from reduced mortality rate. Methods: Data collected related to in-patients’ demographics, clinical, laboratory, therapies and outcome. Primary end-point was time to in-hospital death. Factors associated were evaluated by uni-and multivariable analyses. A flow diagram was created to determine the rate of in-hospital death according to individual and disease characteristics. Results: A total of 1561 patients were included. The 14-day cumulative incidence of in-hospital death by competing risk regression was of 24.8% (95% CI: 21.3–28.5) and 15.9% (95% CI: 13.7–18.2) in the first and second wave. We observed that the highest relative reduction of death from first to second wave (more than 47%) occurred mainly in the clusters of patients younger than 70 years. Conclusions: Progress in care and supporting therapies did affect population over 70 years to a lesser extent. Preventive and vaccination campaigns should focus on individuals whose risk of death from COVID-19 remains high.
age; COVID-19; First and second wave of epidemics; Hospitalised patients; In-hospital mortality rate
Settore MED/17 - Malattie Infettive
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/900972
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