Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp) has been endemic in Italy since 2013. In a multicenter cohort study, we investigated various aspects of KPC-Kp among patients, including 15-day mortality rates and delays in adequate therapy. Most (77%) KPC-Kp strains were sequence types ST512 or ST307. During 2017, KPC-Kp prevalence was 3.26 cases/1,000 hospitalized patients. Cumulative incidence of KPC-Kp acquired >48 hours after hospital admission was 0.68% but varied widely between centers. Among patients with mild infections and noninfected colonized patients, 15-day mortality rates were comparable, but rates were much higher among patients with severe infections. Delays of >4 days in receiving adequate therapy more frequently occurred among patients with mild infections than those with severe infections, and delays were less common for patients with known previous KPC-Kp colonization. Italy urgently needs a concerted surveillance system to control the spread of KPC-Kp.

Characteristics and clinical implications of carbapenemase-producing klebsiella pneumoniae colonization and infection, Italy / M. Rossi, L. Chatenoud, F. Gona, I. Sala, G. Nattino, A. D'Antonio, D. Castelli, T. Itri, P. Morelli, S. Bigoni, C. Aldieri, R. Martegani, P.A. Grossi, C. Del Curto, S. Piconi, S.G. Rimoldi, P. Brambilla, P. Bonfanti, E. van Hauwermeiren, M. Puoti, G. Gattuso, C. Cerri, M.C. Raviglione, D.M. Cirillo, A. Bandera, A. Gori, S. Battaglia, G. Lorenzin, A. Cavallero, M. Casana, D. Pocaterra, A. Cona, A. D'Arminio Monforte, G. Brigante, A. Carducci, D. Dalla Gasperina, C. Rovelli, M. Moro, P. Scarpellini, G. Rizzardini, A. Pan, A. Zoncada, M. Franzetti, A. Pandolfo, F. Castelli, E. Pollastri, G. Travi, C.S. Vismara, S. Garilli, M. Piazza, A. Regazzetti, M. Arghittu, R.M. Colombo, P. Olivieri, F. Petri, F. Averara, F. Vailati. - In: EMERGING INFECTIOUS DISEASES. - ISSN 1080-6040. - 27:5(2021 May), pp. 1416-1426. [10.3201/eid2705.203662]

Characteristics and clinical implications of carbapenemase-producing klebsiella pneumoniae colonization and infection, Italy

Chatenoud L.;D'Antonio A.;Aldieri C.;Martegani R.;Del Curto C.;Piconi S.;Rimoldi S. G.;Bonfanti P.;Raviglione M. C.;Bandera A.;Gori A.;Battaglia S.;Casana M.;Cona A.;D'Arminio Monforte A.;Rovelli C.;Pandolfo A.;Vismara C. S.;Arghittu M.;Petri F.;
2021-05

Abstract

Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp) has been endemic in Italy since 2013. In a multicenter cohort study, we investigated various aspects of KPC-Kp among patients, including 15-day mortality rates and delays in adequate therapy. Most (77%) KPC-Kp strains were sequence types ST512 or ST307. During 2017, KPC-Kp prevalence was 3.26 cases/1,000 hospitalized patients. Cumulative incidence of KPC-Kp acquired >48 hours after hospital admission was 0.68% but varied widely between centers. Among patients with mild infections and noninfected colonized patients, 15-day mortality rates were comparable, but rates were much higher among patients with severe infections. Delays of >4 days in receiving adequate therapy more frequently occurred among patients with mild infections than those with severe infections, and delays were less common for patients with known previous KPC-Kp colonization. Italy urgently needs a concerted surveillance system to control the spread of KPC-Kp.
CRE; Carbapenem resistance; Enterobacteriaceae; Italy; KPC-Kp; Klebsiella pneumoniae; antimicrobial resistance; bacteria; healthcare-associated infections; mortality rates; Anti-Bacterial Agents; Bacterial Proteins; Humans; Italy; Klebsiella pneumoniae; beta-Lactamases; Carbapenem-Resistant Enterobacteriaceae; Klebsiella Infections
Settore MED/17 - Malattie Infettive
EMERGING INFECTIOUS DISEASES
Article (author)
File in questo prodotto:
File Dimensione Formato  
20-3662.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 2.76 MB
Formato Adobe PDF
2.76 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/899789
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 0
social impact