Deep brain stimulation (DBS) is used for the treatment of movement disorders, including Parkinson’s disease, dystonia, and essential tremor, and has shown clinical benefits in other brain disorders. A natural path for the improvement of this technique is to continuously observe the stimulation effects on patient symptoms and neurophysiological markers. This requires the evolution of conventional deep brain stimulators to bidirectional interfaces, able to record, process, store, and wirelessly communicate neural signals in a robust and reliable fashion. Here, we present the architecture, design, and first use of an implantable stimulation and sensing interface (AlphaDBSR System) characterized by artifact-free recording and distributed data management protocols. Its application in three patients with Parkinson’s disease (clinical trial n. NCT04681534) is shown as a proof of functioning of a clinically viable implanted brain-computer interface (BCI) for adaptive DBS. Reliable artifact free-recordings, and chronic long-term data and neural signal management are in place.

A New Implantable Closed-Loop Clinical Neural Interface: First Application in Parkinson’s Disease / M. Arlotti, M. Colombo, A. Bonfanti, T. Mandat, M.M. Lanotte, E. Pirola, L. Borellini, P. Rampini, R. Eleopra, S. Rinaldo, L. Romito, M.L.F. Janssen, A. Priori, S. Marceglia. - In: FRONTIERS IN NEUROSCIENCE. - ISSN 1662-4548. - 15(2021 Dec 07), pp. 763235.1-763235.12. [10.3389/fnins.2021.763235]

A New Implantable Closed-Loop Clinical Neural Interface: First Application in Parkinson’s Disease

L. Borellini;S. Rinaldo;A. Priori
Penultimo
;
2021-12-07

Abstract

Deep brain stimulation (DBS) is used for the treatment of movement disorders, including Parkinson’s disease, dystonia, and essential tremor, and has shown clinical benefits in other brain disorders. A natural path for the improvement of this technique is to continuously observe the stimulation effects on patient symptoms and neurophysiological markers. This requires the evolution of conventional deep brain stimulators to bidirectional interfaces, able to record, process, store, and wirelessly communicate neural signals in a robust and reliable fashion. Here, we present the architecture, design, and first use of an implantable stimulation and sensing interface (AlphaDBSR System) characterized by artifact-free recording and distributed data management protocols. Its application in three patients with Parkinson’s disease (clinical trial n. NCT04681534) is shown as a proof of functioning of a clinically viable implanted brain-computer interface (BCI) for adaptive DBS. Reliable artifact free-recordings, and chronic long-term data and neural signal management are in place.
closed-loop; deep brain stimulation; implantable device; local field potential (LFP); neural interface; neuromodulation; Parkinson’s disease;
Settore MED/26 - Neurologia
Article (author)
File in questo prodotto:
File Dimensione Formato  
fnins-15-763235.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 7.65 MB
Formato Adobe PDF
7.65 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/896885
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 3
social impact