Tumor development and progression are strongly linked to inflammation and the presence of tumor-associated macrophages (TAMs). In murine tumors, antitumor activity can be achieved by targeting TAM recruitment, survival, activation, polarization, effector signaling, or extracellular matrix interactions. Thus, it may be possible to increase the efficacy of conventional cancer therapeutic strategies by targeting TAMs. (copyright)2005 American Association for Cancer Research.
Targeting myelomonocytic cells to revert inflammation-dependent cancer promotion / A. Mantovani, M.P. Colombo. - In: CANCER RESEARCH. - ISSN 0008-5472. - 65:20(2005 Oct 15), pp. 9113-9116. [10.1158/0008-5472.CAN-05-2714]
Targeting myelomonocytic cells to revert inflammation-dependent cancer promotion
A. MantovaniPrimo
;
2005
Abstract
Tumor development and progression are strongly linked to inflammation and the presence of tumor-associated macrophages (TAMs). In murine tumors, antitumor activity can be achieved by targeting TAM recruitment, survival, activation, polarization, effector signaling, or extracellular matrix interactions. Thus, it may be possible to increase the efficacy of conventional cancer therapeutic strategies by targeting TAMs. (copyright)2005 American Association for Cancer Research.
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