To the SLC6 family belong 20 human transporters that utilize the sodium electrochemical gradient to move biogenic amines, osmolytes, amino acids and related compounds into cells. They are classified into two functional groups, the Neurotransmitter transporters (NTT) and Nutrient amino acid transporters (NAT). Here we summarize how since their first cloning in 1998, the insect (Lepidopteran) Orthologs of the SLC6 family transporters have represented very important tools for investigating functional-structural relationships, mechanism of transport, ion and pH dependence and substate interaction of the mammalian (and human) counterparts.

The Lepidopteran KAAT1 and CAATCH1: Orthologs to Understand Structure-Function Relationships in Mammalian SLC6 Transporters / M. Castagna, R. Cinquetti, T. Verri, F. Vacca, M. Giovanola, A. Barca, T. Romanazzi, C. Roseti, A. Galli, E. Bossi. - In: NEUROCHEMICAL RESEARCH. - ISSN 0364-3190. - (2021), pp. 1-16. [Epub ahead of print] [10.1007/s11064-021-03410-1]

The Lepidopteran KAAT1 and CAATCH1: Orthologs to Understand Structure-Function Relationships in Mammalian SLC6 Transporters

M. Castagna
Primo
;
M. Giovanola;A. Galli;
2021

Abstract

To the SLC6 family belong 20 human transporters that utilize the sodium electrochemical gradient to move biogenic amines, osmolytes, amino acids and related compounds into cells. They are classified into two functional groups, the Neurotransmitter transporters (NTT) and Nutrient amino acid transporters (NAT). Here we summarize how since their first cloning in 1998, the insect (Lepidopteran) Orthologs of the SLC6 family transporters have represented very important tools for investigating functional-structural relationships, mechanism of transport, ion and pH dependence and substate interaction of the mammalian (and human) counterparts.
ACE2; Electrophysiology; Membrane transporters; Neurotransmitter transporters; Nutrient transporters; SLC6; Xenopus laevis oocytes
Settore BIO/09 - Fisiologia
24-lug-2021
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/890962
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