Film-coating is widely applied in pharmaceutics to enhance aspect/taste and mechanical properties of dosage forms, to protect them from the environment and to modify their release performance. In this respect, a film-coating process was recently involved in the development of 4D printed prolonged-release systems intended for organ retention. During coating processes, liquid formulations are sprayed onto moving cores, whose shape, weight and surface characteristics are essential to attain a homogeneous film. Devices of complex shapes, composed of smart materials and fabricated by hot-processing techniques, such as extrusion and fused deposition modeling 3D printing, might be poorly compatible with the requirements of traditional coating methods, e.g., need for spherical substrates with smooth surface and stable under process temperatures. This work was aimed at evaluating, at a small scale level, the feasibility of a versatile equipment for film-coating of rod-shaped extruded and printed prototypes with different section. Equipment design and set up of process parameters were performed starting from polymeric solutions and suspensions and selecting as cores 50 mm-long rod-shaped samples based on shape memory poly(vinyl alcohol). Integrity and thickness of the applied layer and its impact on shape memory and release performance of prototypes were investigated.

Dataset on a small-scale film-coating process developed for self-expanding 4D printed drug delivery devices / M. Uboldi, A. Melocchi, S. Moutaharrik, M. Cerea, A. Gazzaniga, L. Zema. - In: COATINGS. - ISSN 2079-6412. - 11:10(2021 Oct 14), pp. 1252.1-1252.9. [10.3390/coatings11101252]

Dataset on a small-scale film-coating process developed for self-expanding 4D printed drug delivery devices

M. Uboldi
Primo
;
A. Melocchi
Secondo
;
S. Moutaharrik;M. Cerea;A. Gazzaniga
Penultimo
;
L. Zema
Ultimo
2021

Abstract

Film-coating is widely applied in pharmaceutics to enhance aspect/taste and mechanical properties of dosage forms, to protect them from the environment and to modify their release performance. In this respect, a film-coating process was recently involved in the development of 4D printed prolonged-release systems intended for organ retention. During coating processes, liquid formulations are sprayed onto moving cores, whose shape, weight and surface characteristics are essential to attain a homogeneous film. Devices of complex shapes, composed of smart materials and fabricated by hot-processing techniques, such as extrusion and fused deposition modeling 3D printing, might be poorly compatible with the requirements of traditional coating methods, e.g., need for spherical substrates with smooth surface and stable under process temperatures. This work was aimed at evaluating, at a small scale level, the feasibility of a versatile equipment for film-coating of rod-shaped extruded and printed prototypes with different section. Equipment design and set up of process parameters were performed starting from polymeric solutions and suspensions and selecting as cores 50 mm-long rod-shaped samples based on shape memory poly(vinyl alcohol). Integrity and thickness of the applied layer and its impact on shape memory and release performance of prototypes were investigated.
film-coating; controlled release; shape memory effect; hot melt extrusion; fused deposition modeling; 4D printing; poly(vinyl alcohol); methacrylic acid copolymers
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/877675
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