Many labeled compounds are used as radiopharmaceuticals (RP), for emission imaging and metabolic radiotherapy and contain as labeling agents γ, β-, β+, monochromatic e- and α emitting radionuclides (RN). These labeled compounds very often contain unexpected radionuclidic impurities. Some long-lived isotopic and non-isotopic impurities lead to undesirable radiation doses to the patient and his relatives, as well as to medical/paramedical personnel, other than the general population, due to rad-waste of contaminated specimen and excretion of biological fluids. Use was made of liquid scintillation counting/spectrometry (LSCS) for the detection of tiny amounts of charged particle emitting impurities in RPs labeled with 64Cu, 67Ga, 90Y, 90Sr/ 90Y, 123I, 153Sm, 177Lu and 201Tl.
|Titolo:||The use of liquid scintillation counting as a very sensitive radioanalytical tool for the determination of alpha, beta and electron emitting impurities in radiopharmaceutical compounds|
|Autori interni:||GROPPI GARLANDINI, FLAVIA MARIA (Primo)|
BONARDI, MAURO (Ultimo)
MAINARDI, HAE SONG (Secondo)
MARTINOTTI, ANNA STEFANIA
MORZENTI, SABRINA (Penultimo)
|Parole Chiave:||dosimetry; pharmaceuticals; radiation therapy; radioactive chemical analysis; radioactive tracers; radioisotope imaging; radioisotopes; spectrochemical analysis|
|Settore Scientifico Disciplinare:||Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)|
Settore CHIM/03 - Chimica Generale e Inorganica
|Data di pubblicazione:||gen-2005|
|Digital Object Identifier (DOI):||10.1007/s10967-005-0086-1|
|Appare nelle tipologie:||01 - Articolo su periodico|
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