DNA double-strand breaks (DSBs) are highly hazardous for genome integrity, but meiotic cells deliberately introduce them into their genome in order to initiate homologous recombination, which ensures proper homologous chromosome segregation. To minimize the risk of deleterious effects, meiotic DSB formation, processing and repair are tightly regulated in order to occur only at the right time and place. Furthermore, a highly conserved signal-transduction pathway, called meiotic recombination checkpoint, coordinates DSB repair with meiotic progression and promotes meiotic recombination.
DNA double-strand breaks in meiosis : Checking their formation, processing and repair / M.P. Longhese, D. Bonetti, I. Guerini, N. Manfrini, M. Clerici. - In: DNA REPAIR. - ISSN 1568-7864. - 8:9(2009), pp. 1127-1138. [10.1016/j.dnarep.2009.04.005]
DNA double-strand breaks in meiosis : Checking their formation, processing and repair
N. Manfrini;
2009
Abstract
DNA double-strand breaks (DSBs) are highly hazardous for genome integrity, but meiotic cells deliberately introduce them into their genome in order to initiate homologous recombination, which ensures proper homologous chromosome segregation. To minimize the risk of deleterious effects, meiotic DSB formation, processing and repair are tightly regulated in order to occur only at the right time and place. Furthermore, a highly conserved signal-transduction pathway, called meiotic recombination checkpoint, coordinates DSB repair with meiotic progression and promotes meiotic recombination.File | Dimensione | Formato | |
---|---|---|---|
2_DNA_repair_2009.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
1.15 MB
Formato
Adobe PDF
|
1.15 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.