Grape seed extract (GSE), a naturally producing polyphenolic compound, is found to be a potent hostmodulatory agent and considered for management of periodontal disease. Its anti-bacterial, antioxidant, and anti-inflammatory property may aid in achieving periodontal health. To assess the clinical efficacy of GSE in adjunct to scaling and root planing (SRP) in healing of periodontal pockets. The present study was a longitudinal, parallel design, randomized clinical trial. Seventy-two patients (mean age 39.2±8.6 years) with periodontal pockets were randomly divided into two groups; Test group received intra-pocket delivery of GSE with SRP and Control group received SRP alone. The clinical parameters like Plaque Index (PI), Gingival Index (GI), Probing Depth (PD) and Relative Attachment Level (RAL) were recorded at baseline and 3 months. 64 patients completed the study. Test group at the end of 3 months had statistically significant reduced PD (p=0.002) and RAL (p=0.01). No significant difference was observed for PI and GI at the end of 3 months. Intra-pocket application of GSE with SRP could be beneficial in management of periodontal pockets.

Clinical efficacy of grape seed extract as an adjuvant to scaling and root planing in treatment of periodontal pockets / M. Das, A.C. Das, S. Panda, A. Greco Lucchina, R. Mohanty, B. Manfredi, M. Rovati, M.S. Giacomello, L. Colletti, C. Mortellaro, A. Satpathy, M. Del Fabbro. - In: JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS. - ISSN 0393-974X. - 35:2 Suppl. 1(2021 Apr), pp. 89-96. [10.23812/21-2supp1-8]

Clinical efficacy of grape seed extract as an adjuvant to scaling and root planing in treatment of periodontal pockets

Panda, S;Manfredi, B;Rovati, M;Colletti, L;Del Fabbro, M
2021-04

Abstract

Grape seed extract (GSE), a naturally producing polyphenolic compound, is found to be a potent hostmodulatory agent and considered for management of periodontal disease. Its anti-bacterial, antioxidant, and anti-inflammatory property may aid in achieving periodontal health. To assess the clinical efficacy of GSE in adjunct to scaling and root planing (SRP) in healing of periodontal pockets. The present study was a longitudinal, parallel design, randomized clinical trial. Seventy-two patients (mean age 39.2±8.6 years) with periodontal pockets were randomly divided into two groups; Test group received intra-pocket delivery of GSE with SRP and Control group received SRP alone. The clinical parameters like Plaque Index (PI), Gingival Index (GI), Probing Depth (PD) and Relative Attachment Level (RAL) were recorded at baseline and 3 months. 64 patients completed the study. Test group at the end of 3 months had statistically significant reduced PD (p=0.002) and RAL (p=0.01). No significant difference was observed for PI and GI at the end of 3 months. Intra-pocket application of GSE with SRP could be beneficial in management of periodontal pockets.
grape seed extract; periodontal pocket; periodontitis; pro-anthocyanidines; root planing and scaling; Adult; Dental Plaque Index; Dental Scaling; Follow-Up Studies; Humans; Middle Aged; Periodontal Attachment Loss; Periodontal Pocket; Root Planing; Treatment Outcome; Chronic Periodontitis; Grape Seed Extract; Periodontitis
Settore MED/50 - Scienze Tecniche Mediche Applicate
Settore MED/28 - Malattie Odontostomatologiche
JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/860758
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