BACKGROUND: In heart failure, the exercise gas exchange Weber (A to D) and ventilatory classifications (VC-1 to VC-4) his-torically define disease severity and prognosis. However, their applications in the modern heart failure population of any left ventricular ejection fraction combined with hemodynamics are undefined. We aimed at revisiting and implementing these classifications by cardiopulmonary exercise testing imaging. METHODS AND RESULTS: 269 patients with heart failure with reduced (n=105), mid-range (n=88) and preserved (n=76) ejection fraction underwent cardiopulmonary exercise testing imaging, primarily assessing the cardiac output (CO), mitral regurgita-tion, and mean pulmonary arterial pressure (mPAP)/CO slope. Within both classes, a progressively lower exercise CO, higher mPAP/CO slopes, and mitral regurgitation (P<0.01 all) were observed. After adjustment for age and sex, Cox proportional hazard regression analyses showed that Weber (hazard ratio [HR], 2.9; 95% CI, 1.8–4.7; P<0.001) and ventilatory classes (HR, 1.4; 95% CI, 1.1–2.0; P=0.017) were independently associated with outcome. The best stratification was observed when combining Weber (A/B or C/D) with severe ventilation inefficiency (VC-4) (HR, 2.7; 95% CI, 1.6–4.8; P<0.001). At multivariable analysis the best hemodynamic determinants of peak oxygen consumption and ventilation to carbon dioxide production slope were CO (β-coefficient, 0.72±0.16; P<0.001) and mPAP/CO slope (β-coefficient, 0.72±0.16; P<0.001), respectively. CONCLUSIONS: In the contemporary heart failure population, the Weber and ventilatory classifications maintain their prognostic ability, especially when combined. Exercise CO and mPAP/CO slope are the best predictors of peak oxygen consumption and ventilation to carbon dioxide production slope classifications representing the main targets of interventions to impact functional class and, likely, event rate.

Revisiting and implementing the weber and ventilatory functional classifications in heart failure by cardiopulmonary imaging phenotyping / M. Guazzi, B. Borlaug, M. Metra, M. Losito, F. Bandera, E. Alfonzetti, S. Boveri, T. Sugimoto. - In: JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE. - ISSN 2047-9980. - 10:5(2021 Mar 02), pp. e018822.1-e018822.14. [10.1161/JAHA.120.018822]

Revisiting and implementing the weber and ventilatory functional classifications in heart failure by cardiopulmonary imaging phenotyping

M. Guazzi
Primo
;
M. Losito;F. Bandera;
2021-03-02

Abstract

BACKGROUND: In heart failure, the exercise gas exchange Weber (A to D) and ventilatory classifications (VC-1 to VC-4) his-torically define disease severity and prognosis. However, their applications in the modern heart failure population of any left ventricular ejection fraction combined with hemodynamics are undefined. We aimed at revisiting and implementing these classifications by cardiopulmonary exercise testing imaging. METHODS AND RESULTS: 269 patients with heart failure with reduced (n=105), mid-range (n=88) and preserved (n=76) ejection fraction underwent cardiopulmonary exercise testing imaging, primarily assessing the cardiac output (CO), mitral regurgita-tion, and mean pulmonary arterial pressure (mPAP)/CO slope. Within both classes, a progressively lower exercise CO, higher mPAP/CO slopes, and mitral regurgitation (P<0.01 all) were observed. After adjustment for age and sex, Cox proportional hazard regression analyses showed that Weber (hazard ratio [HR], 2.9; 95% CI, 1.8–4.7; P<0.001) and ventilatory classes (HR, 1.4; 95% CI, 1.1–2.0; P=0.017) were independently associated with outcome. The best stratification was observed when combining Weber (A/B or C/D) with severe ventilation inefficiency (VC-4) (HR, 2.7; 95% CI, 1.6–4.8; P<0.001). At multivariable analysis the best hemodynamic determinants of peak oxygen consumption and ventilation to carbon dioxide production slope were CO (β-coefficient, 0.72±0.16; P<0.001) and mPAP/CO slope (β-coefficient, 0.72±0.16; P<0.001), respectively. CONCLUSIONS: In the contemporary heart failure population, the Weber and ventilatory classifications maintain their prognostic ability, especially when combined. Exercise CO and mPAP/CO slope are the best predictors of peak oxygen consumption and ventilation to carbon dioxide production slope classifications representing the main targets of interventions to impact functional class and, likely, event rate.
Exercise gas exchange; Peak VO; 2; VE/VCO; 2; slope
Settore MED/11 - Malattie dell'Apparato Cardiovascolare
Article (author)
File in questo prodotto:
File Dimensione Formato  
JAHA.120.018822.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 889.12 kB
Formato Adobe PDF
889.12 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/858986
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 3
social impact