Background: As the coronavirus pandemic spreads, more and more people are infected with severe acute respiratory syndrome coronavirus 2. The short- and medium-term effects of the infection have been described, but the description of the long-term sequelae is lacking in the literature. Methods: Patients healed from coronavirus disease 2019 (COVID-19) from February 2020 to May 2020 were considered for inclusion in this study, regardless of the severity of the disease during the acute phase. Eligible patients were consecutively contacted and a semistructured interview was administered between February and March 2021 by trained medical staff. Results: Three hundred three patients were eligible and accepted to participate in the study and were enrolled. Of those surveyed, most patients (81%) reported at least 1 symptom, and the most prevalent symptoms were fatigue (52%), pain (48%), and sleep disorders (47%). Sensory alterations were present in 28% of surveyed patients, but in most of these cases (74% of those affected by sensory alterations or 20% of the overall sample) symptoms reported were either anosmia or dysgeusia. Higher prevalence was generally observed with increasing age, although the most relevant differences were observed when comparing young versus middle-aged adults. Conclusions: At 12 months after acute infection, COVID-19 survivors were still suffering from symptoms identified at shorter follow-up, and the most frequent symptoms included fatigue, pain, and sleep disorders. A more severe impairment in the acute phase did not seem to predict more severe complications.

Long term COVID-19 complications in inpatients and outpatients: a one-year follow up cohort study / M.D.M. Lombardo, A. Foppiani, G. Peretti, L. Mangiavini, A. Battezzati, S. Bertoli, F. Martinelli Boneschi, G.V. Zuccotti. - In: OPEN FORUM INFECTIOUS DISEASES. - ISSN 2328-8957. - (2021). [Epub ahead of print] [10.1093/ofid/ofab384]

Long term COVID-19 complications in inpatients and outpatients: a one-year follow up cohort study

M.D.M. Lombardo
Co-primo
;
A. Foppiani
Co-primo
;
G. Peretti;L. Mangiavini;A. Battezzati;S. Bertoli;F. Martinelli Boneschi
Penultimo
;
G.V. Zuccotti
Ultimo
2021

Abstract

Background: As the coronavirus pandemic spreads, more and more people are infected with severe acute respiratory syndrome coronavirus 2. The short- and medium-term effects of the infection have been described, but the description of the long-term sequelae is lacking in the literature. Methods: Patients healed from coronavirus disease 2019 (COVID-19) from February 2020 to May 2020 were considered for inclusion in this study, regardless of the severity of the disease during the acute phase. Eligible patients were consecutively contacted and a semistructured interview was administered between February and March 2021 by trained medical staff. Results: Three hundred three patients were eligible and accepted to participate in the study and were enrolled. Of those surveyed, most patients (81%) reported at least 1 symptom, and the most prevalent symptoms were fatigue (52%), pain (48%), and sleep disorders (47%). Sensory alterations were present in 28% of surveyed patients, but in most of these cases (74% of those affected by sensory alterations or 20% of the overall sample) symptoms reported were either anosmia or dysgeusia. Higher prevalence was generally observed with increasing age, although the most relevant differences were observed when comparing young versus middle-aged adults. Conclusions: At 12 months after acute infection, COVID-19 survivors were still suffering from symptoms identified at shorter follow-up, and the most frequent symptoms included fatigue, pain, and sleep disorders. A more severe impairment in the acute phase did not seem to predict more severe complications.
COVID pandemic; COVID sequelae; COVID-19; long COVID
Settore MED/33 - Malattie Apparato Locomotore
Settore MED/26 - Neurologia
Settore BIO/09 - Fisiologia
Settore MED/49 - Scienze Tecniche Dietetiche Applicate
Settore MED/38 - Pediatria Generale e Specialistica
16-lug-2021
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/858950
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