This study attempted to replicate previous findings of decreased gray matter content in the subgenual prefrontal cortex (SGPFC) in mood disorder patients. Eighteen DSM-IV unipolar patients, 27 DSM-IV bipolar patients, and 38 healthy controls were studied. A 1.5T GE Signa Imaging System with Signa 5.4.3 software was used. The semi-automated software MedX (Sensor Systems, Sterling, VA) was utilized for the anatomical measures of SGPFC volumes. There were no significant differences in SGPFC volumes in familial and non-familial unipolar and bipolar patients compared with healthy controls, nor between drug-free and lithium-treated bipolar patients (ANOVA, p >. 05). In vivo abnormalities in the volumes of SGPFC were not identified in mildly depressed or euthymic unipolar or bipolar mood disorder outpatients, either familial or non-familial.

Anatomical MRI study of subgenual prefrontal cortex in bipolar and unipolar subjects / P. Brambilla, M.A. Nicoletti, K. Harenski, R.B. Sassi, A.G. Mallinger, E. Frank, D.J. Kupfer, M.S. Keshavan, J.C. Soares. - In: NEUROPSYCHOPHARMACOLOGY. - ISSN 0893-133X. - 27:5(2002), pp. 792-799.

Anatomical MRI study of subgenual prefrontal cortex in bipolar and unipolar subjects

P. Brambilla;
2002

Abstract

This study attempted to replicate previous findings of decreased gray matter content in the subgenual prefrontal cortex (SGPFC) in mood disorder patients. Eighteen DSM-IV unipolar patients, 27 DSM-IV bipolar patients, and 38 healthy controls were studied. A 1.5T GE Signa Imaging System with Signa 5.4.3 software was used. The semi-automated software MedX (Sensor Systems, Sterling, VA) was utilized for the anatomical measures of SGPFC volumes. There were no significant differences in SGPFC volumes in familial and non-familial unipolar and bipolar patients compared with healthy controls, nor between drug-free and lithium-treated bipolar patients (ANOVA, p >. 05). In vivo abnormalities in the volumes of SGPFC were not identified in mildly depressed or euthymic unipolar or bipolar mood disorder outpatients, either familial or non-familial.
Affective disorders; Bipolar disorder; Depression; Magnetic resonance imaging; Mood disorders; Neuroimaging; Unipolar disorder
Settore MED/25 - Psichiatria
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/851880
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