AbstractBackground:Information about the renin–angiotensin–aldosterone system (RAAS) in obese individuals before and after bariatric surgery is scarce. Aim of this study was to analyze the RAAS in severely obese subjects, in relation to anthropometric and metabolic variables, with special reference to glucose tolerance.Methods:239 subjects were evaluated at baseline, and 181 one year after bariatric surgery [laparoscopic gastric banding (LAGB)].Results:At baseline, renin (plasma renin activity, PRA) was increased from normal to glucose tolerance and more in diabetes, also correlating with ferritin. After LAGB, the decrease of PRA and aldosterone was significant in hyperten-sive, but not in normotensive subjects, and correlatied with decrease of ferritin. PRA and glucose levels were predic-tive of persistent hypertension 1 year after LAGB.Conclusions:These data support the role of RAAS in the pathophysiology of glucose homeostasis, and in the regula-tion of blood pressure in obesity. Ferritin, as a proxy of subclinical inflammation, could be another factor contributing to the cross-talk between RAAS and glucose metabolism.

High plasma renin activity associates with obesity-related diabetes and arterial hypertension, and predicts persistent hypertension after bariatric surgery / L. La Sala, E. Tagliabue, E. Vieira, A.E. Pontiroli, F. Folli. - In: CARDIOVASCULAR DIABETOLOGY. - ISSN 1475-2840. - 20:1(2021), pp. 1-12.

High plasma renin activity associates with obesity-related diabetes and arterial hypertension, and predicts persistent hypertension after bariatric surgery

E. Tagliabue
Membro del Collaboration Group
;
A.E. Pontiroli
Penultimo
Writing – Original Draft Preparation
;
F. Folli
Ultimo
Supervision
2021

Abstract

AbstractBackground:Information about the renin–angiotensin–aldosterone system (RAAS) in obese individuals before and after bariatric surgery is scarce. Aim of this study was to analyze the RAAS in severely obese subjects, in relation to anthropometric and metabolic variables, with special reference to glucose tolerance.Methods:239 subjects were evaluated at baseline, and 181 one year after bariatric surgery [laparoscopic gastric banding (LAGB)].Results:At baseline, renin (plasma renin activity, PRA) was increased from normal to glucose tolerance and more in diabetes, also correlating with ferritin. After LAGB, the decrease of PRA and aldosterone was significant in hyperten-sive, but not in normotensive subjects, and correlatied with decrease of ferritin. PRA and glucose levels were predic-tive of persistent hypertension 1 year after LAGB.Conclusions:These data support the role of RAAS in the pathophysiology of glucose homeostasis, and in the regula-tion of blood pressure in obesity. Ferritin, as a proxy of subclinical inflammation, could be another factor contributing to the cross-talk between RAAS and glucose metabolism.
Renin; Aldosterone; Diabetes; HOMA index; Hypertension; Obesity; Weight loss; Bariatric surgery; Laparoscopic gastric banding (LAGB); Ferritin
Settore MED/09 - Medicina Interna
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/849618
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