Mitochondria are organelles with recognized key roles in cellular homeostasis, including bioenergetics, redox, calcium signaling, and cell death. Mitochondria are essential for neuronal function, given the high energy demands of the human brain. Consequently, mitochondrial diseases affecting oxidative phosphorylation (OXPHOS) commonly exhibit neurological impairment. Emerging evidence suggests that mitochondria are important not only for mature postmitotic neurons but also for the regulation of neural progenitor cells (NPCs) during the process of neurogenesis. These recent findings put mitochondria as central regulator of cell fate decisions during brain development. OXPHOS mutations may disrupt the function of NPCs and thereby impair the metabolic programming required for neural fate commitment. Promoting the mitochondrial function of NPCs could therefore represent a novel interventional approach against incurable mitochondrial diseases.

Mitochondria in neurogenesis: Implications for mitochondrial diseases / D. Brunetti, W. Dykstra, S. Le, A. Zink, A. Prigione. - In: STEM CELLS. - ISSN 1549-4918. - (2021). [Epub ahead of print]

Mitochondria in neurogenesis: Implications for mitochondrial diseases

D. Brunetti
Primo
;
2021

Abstract

Mitochondria are organelles with recognized key roles in cellular homeostasis, including bioenergetics, redox, calcium signaling, and cell death. Mitochondria are essential for neuronal function, given the high energy demands of the human brain. Consequently, mitochondrial diseases affecting oxidative phosphorylation (OXPHOS) commonly exhibit neurological impairment. Emerging evidence suggests that mitochondria are important not only for mature postmitotic neurons but also for the regulation of neural progenitor cells (NPCs) during the process of neurogenesis. These recent findings put mitochondria as central regulator of cell fate decisions during brain development. OXPHOS mutations may disrupt the function of NPCs and thereby impair the metabolic programming required for neural fate commitment. Promoting the mitochondrial function of NPCs could therefore represent a novel interventional approach against incurable mitochondrial diseases.
iPSCs; mitochondria; mitochondrial diseases; neurogenesis; NPCs;
Settore BIO/14 - Farmacologia
5-giu-2021
https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/stem.3425
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/849093
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