Shape memory materials (SMMs), including alloys and polymers, can be programmed into a temporary configuration and then recover the original shape in which they were processed in response to a triggering external stimulus (e.g. change in temperature or pH, contact with water). For this behavior, SMMs are currently raising a lot of attention in the pharmaceutical field where they could bring about important innovations in the current treatments. 4D printing involves processing of SMMs by 3D printing, thus adding shape evolution over time to the already numerous customization possibilities of this new manufacturing technology. SMM-based drug delivery systems (DDSs) proposed in the scientific literature were here reviewed and classified according to the target pursued through the shape recovery process. Administration route, therapeutic goal, temporary and original shape, triggering stimulus, main innovation features and possible room for improvement of the DDSs were especially highlighted.

Shape memory materials and 4D printing in pharmaceutics / A. Melocchi, M. Uboldi, M. Cerea, A. Foppoli, A. Maroni, S. Moutaharrik, L. Palugan, L. Zema, A. Gazzaniga. - In: ADVANCED DRUG DELIVERY REVIEWS. - ISSN 0169-409X. - 173:(2021 Mar 25), pp. 216-237. [10.1016/j.addr.2021.03.013]

Shape memory materials and 4D printing in pharmaceutics

A. Melocchi
Primo
;
M. Uboldi
Secondo
;
M. Cerea;A. Foppoli;A. Maroni;S. Moutaharrik;L. Palugan;L. Zema
Penultimo
;
A. Gazzaniga
Ultimo
2021

Abstract

Shape memory materials (SMMs), including alloys and polymers, can be programmed into a temporary configuration and then recover the original shape in which they were processed in response to a triggering external stimulus (e.g. change in temperature or pH, contact with water). For this behavior, SMMs are currently raising a lot of attention in the pharmaceutical field where they could bring about important innovations in the current treatments. 4D printing involves processing of SMMs by 3D printing, thus adding shape evolution over time to the already numerous customization possibilities of this new manufacturing technology. SMM-based drug delivery systems (DDSs) proposed in the scientific literature were here reviewed and classified according to the target pursued through the shape recovery process. Administration route, therapeutic goal, temporary and original shape, triggering stimulus, main innovation features and possible room for improvement of the DDSs were especially highlighted.
3D printing; 4D printing; Controlled release; Drug delivery systems; Shape memory alloys; Shape memory effect; Shape memory polymers
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
25-mar-2021
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/839750
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