The past few years observed a breakthrough of genome sequences of bacteria of Rhodococcus genus with significant biodegradation abilities. Invaluable knowledge from genome data and their functional analysis can be applied to develop and design strategies for attenuating damages caused by hydrocarbon contamination. With the advent of high-throughput -omic technologies, it is currently possible to utilize the functional properties of diverse catabolic genes, analyze an entire system at the level of molecule (DNA, RNA, protein, and metabolite), simultaneously predict and construct catabolic degradation pathways. In this review, the genes involved in the biodegradation of hydrocarbons and several emerging plasticizer compounds in Rhodococcus strains are described in detail (aliphatic, aromatics, PAH, phthalate, polyethylene, and polyisoprene). The metabolic biodegradation networks predicted from omics-derived data along with the catabolic enzymes exploited in diverse biotechnological and bioremediation applications are characterized.

Genome analysis and -omics approaches provide new insights into the biodegradation potential of Rhodococcus / J. Zampolli, Z. Zeaiter, A. Di Canito, P. Di Gennaro. - In: APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. - ISSN 0175-7598. - 103:3(2019 Feb), pp. 1069-1080. [10.1007/s00253-018-9539-7]

Genome analysis and -omics approaches provide new insights into the biodegradation potential of Rhodococcus

A. DI CANITO;P. DI GENNARO
2019

Abstract

The past few years observed a breakthrough of genome sequences of bacteria of Rhodococcus genus with significant biodegradation abilities. Invaluable knowledge from genome data and their functional analysis can be applied to develop and design strategies for attenuating damages caused by hydrocarbon contamination. With the advent of high-throughput -omic technologies, it is currently possible to utilize the functional properties of diverse catabolic genes, analyze an entire system at the level of molecule (DNA, RNA, protein, and metabolite), simultaneously predict and construct catabolic degradation pathways. In this review, the genes involved in the biodegradation of hydrocarbons and several emerging plasticizer compounds in Rhodococcus strains are described in detail (aliphatic, aromatics, PAH, phthalate, polyethylene, and polyisoprene). The metabolic biodegradation networks predicted from omics-derived data along with the catabolic enzymes exploited in diverse biotechnological and bioremediation applications are characterized.
Rhodococcus; -omics; Biodegradation; Recalcitrant compounds; Gene cluster
Settore BIO/19 - Microbiologia Generale
15-dic-2018
Article (author)
File in questo prodotto:
File Dimensione Formato  
Zampolli et al. 2018.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 749.76 kB
Formato Adobe PDF
749.76 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Zampolli2019_Article_GenomeAnalysisAnd-omicsApproac.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 725.83 kB
Formato Adobe PDF
725.83 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/838756
Citazioni
  • ???jsp.display-item.citation.pmc??? 15
  • Scopus 35
  • ???jsp.display-item.citation.isi??? 28
social impact