Stilbenoids (resveratrol and its derivatives) are secondary metabolites produced by plants as defence mechanism to microbial infection. These compounds are known for their anti-inflammatory action and health benefits in preventing a wide range of disorders (e.g. cancer and cardiovascular diseases). However, their antimicrobial properties are less investigated. A series of 8 stilbenoid compounds were synthesized and their antifungal activity against 19 wild strains of filamentous fungi and yeasts (isolated from the environment and food) was tested in vitro. Using an agar diffusion assay, compounds were tested at the concentration of 100 μg/ml on filamentous fungi and yeasts at 104 CFU/ml. The results showed that tested derivatives possess moderate antifungal activity: in particular, monomeric stilbenoids 3’-hydroxy-pterostilbene and piceatannol, and dimeric stilbenoids (±)-trans-δ-viniferin and pallidol were active against mycotoxigenic fungi.

Inhibitory activity of stilbenes against filamentous fungi / L.M. Mattio, G. Catinella, M. Iriti, L. Vallone. - In: ITALIAN JOURNAL OF FOOD SAFETY. - ISSN 2239-7132. - 10:1(2021 Mar), pp. 8461.1-8461.4. ((Intervento presentato al 29. convegno AIVI tenutosi a Bari nel 2019.

Inhibitory activity of stilbenes against filamentous fungi

L.M. Mattio
Primo
;
G. Catinella
Secondo
;
M. Iriti
Penultimo
Data Curation
;
L. Vallone
Ultimo
Project Administration
2021

Abstract

Stilbenoids (resveratrol and its derivatives) are secondary metabolites produced by plants as defence mechanism to microbial infection. These compounds are known for their anti-inflammatory action and health benefits in preventing a wide range of disorders (e.g. cancer and cardiovascular diseases). However, their antimicrobial properties are less investigated. A series of 8 stilbenoid compounds were synthesized and their antifungal activity against 19 wild strains of filamentous fungi and yeasts (isolated from the environment and food) was tested in vitro. Using an agar diffusion assay, compounds were tested at the concentration of 100 μg/ml on filamentous fungi and yeasts at 104 CFU/ml. The results showed that tested derivatives possess moderate antifungal activity: in particular, monomeric stilbenoids 3’-hydroxy-pterostilbene and piceatannol, and dimeric stilbenoids (±)-trans-δ-viniferin and pallidol were active against mycotoxigenic fungi.
stilbenes; resveratrol; antimicrobial activity; food-borne fungi
Settore VET/04 - Ispezione degli Alimenti di Origine Animale
feb-2021
Associazione Italiana Veterinari Igienisti
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/829901
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