Lippia citriodora is a plant traditionally used for its anti-inflammatory, antioxidant and antispasmodic effects, as well as for additional biological activities proven in cell culture, studies and a small number of human clinical trials. The plant has also shown a marked effect of a leaf extract on lipid and oxidative blood profile of hypercholesterolemic adults received Lippia citriodora extract caps, containing 23% phenylpropanoids, (100 mg, for 16 weeks. Selected blood lipids and plasma oxidative markers were measured at 4, 8 and 16 weeks of treatment. Compared with baseline, total cholesterol levels and high-density lipoprotein cholesterol increased, while low-density lipoprotein triglycerides showed only a downward trend. Oxidative status was improved due to a the concentration of total oxidant status, reactive oxygen metabolites and significant increase in ferric reducing ability of plasma, vitamin A and vitamin E. These results suggest that dietary supplementation with Lippia citriodora extract can improve the enhance blood antioxidant power, and could be a valuable natural compound for the human hypercholesterolemia.

Effects of Lippia citriodora Leaf Extract on Lipid and Oxidative Blood Profile of Volunteers with Hypercholesterolemia : A Preliminary Study / A. Angiolillo, D. Leccese, M. Palazzo, F. Vizzarri, D. Casamassima, C. Corino, A. Di Costanzo. - In: ANTIOXIDANTS. - ISSN 2076-3921. - 10:4(2021 Mar 27), pp. 521.1-521.11. [10.3390/antiox10040521]

Effects of Lippia citriodora Leaf Extract on Lipid and Oxidative Blood Profile of Volunteers with Hypercholesterolemia : A Preliminary Study

C. Corino
Penultimo
;
2021

Abstract

Lippia citriodora is a plant traditionally used for its anti-inflammatory, antioxidant and antispasmodic effects, as well as for additional biological activities proven in cell culture, studies and a small number of human clinical trials. The plant has also shown a marked effect of a leaf extract on lipid and oxidative blood profile of hypercholesterolemic adults received Lippia citriodora extract caps, containing 23% phenylpropanoids, (100 mg, for 16 weeks. Selected blood lipids and plasma oxidative markers were measured at 4, 8 and 16 weeks of treatment. Compared with baseline, total cholesterol levels and high-density lipoprotein cholesterol increased, while low-density lipoprotein triglycerides showed only a downward trend. Oxidative status was improved due to a the concentration of total oxidant status, reactive oxygen metabolites and significant increase in ferric reducing ability of plasma, vitamin A and vitamin E. These results suggest that dietary supplementation with Lippia citriodora extract can improve the enhance blood antioxidant power, and could be a valuable natural compound for the human hypercholesterolemia.
verbascoside; hypercholesterolemia; antioxidants
Settore AGR/18 - Nutrizione e Alimentazione Animale
Settore MED/26 - Neurologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/829383
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