The potential virucidal effects of UV-C irradiation on SARS-CoV-2 were experimentally evaluated for different illumination doses and virus concentrations (1000, 5, 0.05 MOI). At a virus density comparable to that observed in SARS-CoV-2 infection, an UV-C dose of just 3.7mJ/cm2 was sufficient to achieve a more than 3-log inactivation without any sign of viral replication. Moreover, a complete inactivation at all viral concentrations was observed with 16.9mJ/cm2. These results could explain the epidemiological trends of COVID-19 and are important for the development of novel sterilizing methods to contain SARS-CoV-2 infection.

UV-C irradiation is highly effective in inactivating SARS-CoV-2 replication / M. Biasin, A. Bianco, G. Pareschi, A. Cavalleri, C. Cavatorta, C. Fenizia, P. Galli, L. Lessio, M. Lualdi, E. Tombetti, A. Ambrosi, E.M.A. Redaelli, I. Saulle, D. Trabattoni, A. Zanutta, M. Clerici. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 11:1(2021 Dec). [10.1038/s41598-021-85425-w]

UV-C irradiation is highly effective in inactivating SARS-CoV-2 replication

M. Biasin
Primo
;
A. Bianco
Secondo
;
C. Fenizia;M. Lualdi;E. Tombetti;I. Saulle;D. Trabattoni;M. Clerici
Ultimo
2021

Abstract

The potential virucidal effects of UV-C irradiation on SARS-CoV-2 were experimentally evaluated for different illumination doses and virus concentrations (1000, 5, 0.05 MOI). At a virus density comparable to that observed in SARS-CoV-2 infection, an UV-C dose of just 3.7mJ/cm2 was sufficient to achieve a more than 3-log inactivation without any sign of viral replication. Moreover, a complete inactivation at all viral concentrations was observed with 16.9mJ/cm2. These results could explain the epidemiological trends of COVID-19 and are important for the development of novel sterilizing methods to contain SARS-CoV-2 infection.
Settore BIO/13 - Biologia Applicata
Settore MED/04 - Patologia Generale
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/826521
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