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EnglishThe cellular response to cancer-induced stress is one of the major aspects regulating cancer development and progression. The Heat Shock Protein B8 (HSPB8) is a small chaperone involved in chaperone-assisted selective autophagy (CASA). CASA promotes the selective degra-dation of proteins to counteract cell stress such as tumor-induced stress. HSPB8 is also involved in (i) the cell division machinery regulating chromosome segregation and cell cycle arrest in the G0/G1 phase and (ii) inflammation regulating dendritic cell maturation and cytokine production. HSPB8 expression and role are tumor-specific, showing a dual and opposite role. Interestingly, HSPB8 may be involved in the acquisition of chemoresistance to drugs. Despite the fact the mech-anisms of HSPB8-mediated CASA activation in tumors need further studies, HSPB8 could repre-sent an important factor in cancer induction and progression and it may be a potential target for anticancer treatment in specific types of cancer. In this review, we will discuss the molecular mechanism underlying HSPB8 roles in normal and cancer conditions. The basic mechanisms in-volved in anti- and pro-tumoral activities of HSPB8 are deeply discussed together with the pathways that modulate HSPB8 expression, in order to outline molecules with a beneficial effect for cancer cell growth, migration, and death.
The Role of HSPB8, a Component of the Chaperone-Assisted Selective Autophagy Machinery, in Cancer / R.M. Cristofani, M. Piccolella, V. Crippa, B. Tedesco, M. Montagnani Marelli, A. Poletti, R.M. Moretti. - In: CELLS. - ISSN 2073-4409. - 10:2(2021 Feb 05).
| Titolo: | The Role of HSPB8, a Component of the Chaperone-Assisted Selective Autophagy Machinery, in Cancer |
| Autori: | CRISTOFANI, RICCARDO MARIA (Co-primo) PICCOLELLA, MARGHERITA (Co-primo) MORETTI, ROBERTA MANUELA (Ultimo) |
| Parole Chiave: | protein quality control; chaperones; HSPB8; autophagy; CASA; cancer, proteasome |
| Settore Scientifico Disciplinare: | Settore BIO/13 - Biologia Applicata Settore BIO/09 - Fisiologia |
| Progetto: | FON_NAZ19APOLE_03 - Alternative translation initiation as a novel strategy to block toxicity of the mutant Androgen Receptor in SBMA - POLETTI, ANGELO - FON_NAZ - Bandi Altre Fondazioni - 2019 INTLI19RCRIS_01 - Selective translation of androgen receptor isoform A to prevent polyQ mediated toxicity in Kennedy’s disease - CRISTOFANI, RICCARDO MARIA - INTLI - Finanziamenti internazionali - 2019 AL_RIC18APOLE_01 - Colchicine for Amyotrophic Lateral Sclerosis: a phase II, randomized, double blind, placebo controlled, multicenter clinical trial (Co-ALS) - POLETTI, ANGELO - AL_RIC - Bandi da altri enti di ricerca - 2018 PRIN201719APOLE_01 - The interplay between the “rna/protein quality control system” and “exosomes” as a spreading mechanism in amyotrophic lateral sclerosis (EX_ALS) - POLETTI, ANGELO - PRIN2017 - PRIN bando 2017 - 2019 CAR_RIC15APOLE_M - RAN translation of normal and expanded nucleotide repeat containing transcripts to neurotoxic polypetides in neurodegenerative diseases - POLETTI, ANGELO - CAR_RIC - Bandi Fondazione Cariplo - 2015 FON_NAZ19APOLE_01 - Targeting RAN translation in ALS (Target-RAN) - POLETTI, ANGELO - FON_NAZ - Bandi Altre Fondazioni - 2019 JPI_MIUR16APOLE_01 - Stress granules and proteostasis in motor neurons: towards a mechanistic understanding of ALS (CureALS) - POLETTI, ANGELO - JPI_MIUR - Joint Programming Initiatives_MIUR - 2016 FON_NAZ19APOLE_02 - Membrane-less organelle pathology in ALS: identification of causes and rescuing factors (MLOMALS) - POLETTI, ANGELO - FON_NAZ - Bandi Altre Fondazioni - 2019 2013-RIC-0027 - Selective autophagicresponse to proteotoxicity in motorneurons and muscle of motor neurondiseases - POLETTI, ANGELO - INTLI - Finanziamenti internazionali - 2013 FON_NAZ14APOLE_M - Motor neuron degeneration in Spinal and Bulbar Muscular Atrophy: molecular approaches to counteract mutant androgen receptor neurotoxicity - POLETTI, ANGELO - FON_NAZ - Bandi Altre Fondazioni - 2014 FON_NAZ17APOLE_01 - Translating molecular mechanisms into ALS risk and patient's well-being - POLETTI, ANGELO - FON_NAZ - Bandi Altre Fondazioni - 2017 MIS15APOLE_M - Ruolo protettivo della proteina HSPB8 nelle malattie del motoneurone - POLETTI, ANGELO - MIS - Bandi Ministero Salute - 2015 2012-RIC-0028 - Upregulation of HSPB8 as potential therapeutic approach in familial and sporadic ALS - POLETTI, ANGELO - FON_NAZ - Bandi Altre Fondazioni - 2012 |
| Data di pubblicazione: | 5-feb-2021 |
| Rivista: | |
| Tipologia: | Article (author) |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.3390/cells10020335 |
| Appare nelle tipologie: | 01 - Articolo su periodico |
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