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EnglishThe cellular response to cancer-induced stress is one of the major aspects regulating cancer development and progression. The Heat Shock Protein B8 (HSPB8) is a small chaperone involved in chaperone-assisted selective autophagy (CASA). CASA promotes the selective degra-dation of proteins to counteract cell stress such as tumor-induced stress. HSPB8 is also involved in (i) the cell division machinery regulating chromosome segregation and cell cycle arrest in the G0/G1 phase and (ii) inflammation regulating dendritic cell maturation and cytokine production. HSPB8 expression and role are tumor-specific, showing a dual and opposite role. Interestingly, HSPB8 may be involved in the acquisition of chemoresistance to drugs. Despite the fact the mech-anisms of HSPB8-mediated CASA activation in tumors need further studies, HSPB8 could repre-sent an important factor in cancer induction and progression and it may be a potential target for anticancer treatment in specific types of cancer. In this review, we will discuss the molecular mechanism underlying HSPB8 roles in normal and cancer conditions. The basic mechanisms in-volved in anti- and pro-tumoral activities of HSPB8 are deeply discussed together with the pathways that modulate HSPB8 expression, in order to outline molecules with a beneficial effect for cancer cell growth, migration, and death.
The Role of HSPB8, a Component of the Chaperone-Assisted Selective Autophagy Machinery, in Cancer / R.M. Cristofani, M. Piccolella, V. Crippa, B. Tedesco, M. Montagnani Marelli, A. Poletti, R.M. Moretti. - In: CELLS. - ISSN 2073-4409. - 10:2(2021 Feb 05).
| Titolo: | The Role of HSPB8, a Component of the Chaperone-Assisted Selective Autophagy Machinery, in Cancer | |
| Autori: | CRISTOFANI, RICCARDO MARIA (Co-primo) PICCOLELLA, MARGHERITA (Co-primo) MORETTI, ROBERTA MANUELA (Ultimo) | |
| Parole Chiave: | protein quality control; chaperones; HSPB8; autophagy; CASA; cancer, proteasome | |
| Settore Scientifico Disciplinare: | Settore BIO/13 - Biologia Applicata Settore BIO/09 - Fisiologia | |
| Progetto: | Alternative translation initiation as a novel strategy to block toxicity of the mutant Androgen Receptor in SBMA Selective translation of androgen receptor isoform A to prevent polyQ mediated toxicity in Kennedy’s disease Colchicine for Amyotrophic Lateral Sclerosis: a phase II, randomized, double blind, placebo controlled, multicenter clinical trial (Co-ALS) The interplay between the “rna/protein quality control system” and “exosomes” as a spreading mechanism in amyotrophic lateral sclerosis (EX_ALS) RAN translation of normal and expanded nucleotide repeat containing transcripts to neurotoxic polypetides in neurodegenerative diseases Targeting RAN translation in ALS (Target-RAN) Stress granules and proteostasis in motor neurons: towards a mechanistic understanding of ALS (CureALS) Membrane-less organelle pathology in ALS: identification of causes and rescuing factors (MLOMALS) Selective autophagic response to proteotoxicity in motorneurons and muscle of motor neuron diseases Motor neuron degeneration in Spinal and Bulbar Muscular Atrophy: molecular approaches to counteract mutant androgen receptor neurotoxicity Translating molecular mechanisms into ALS risk and patient's well-being Ruolo protettivo della proteina HSPB8 nelle malattie del motoneurone Upregulation of HSPB8 as potential therapeutic approach in familial and sporadic ALS | |
| Data di pubblicazione: | 5-feb-2021 | |
| Rivista: | ||
| Tipologia: | Article (author) | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.3390/cells10020335 | |
| Appare nelle tipologie: | 01 - Articolo su periodico |
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| cells-10-00335.pdf | Publisher's version/PDF | Open Access Visualizza/Apri |
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